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Women become more susceptible to hypertension as they approach menopause, and now a preclinical study led by researchers at Weill Cornell Medicine’s Feil Family Brain and Mind Research Institute suggests that this “perimenopausal” hypertension may be driven by declines in estrogen signaling in a brain region called the hypothalamus—and may be preventable with estrogen-like treatments.

In the...

To enable animals to shift their attention in response to changing circumstances, the prefrontal cortex of the brain helps keep track of which types of stimuli have recently been most relevant, suggests a preclinical study by Weill Cornell Medicine and NewYork-Presbyterian investigators. This discovery could lead to new treatments to help restore cognitive flexibility.

“Animals and people make split-second decisions about what to do in changing circumstances and what to pay attention...

A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice. It is the first map that depicts this important layer of biological diversity, called isoform variation, by cell type and across brain regions for the whole genome, and it contributes to neuroscientists’ ambitious goal of an ultra-detailed atlas of the brain.

Isoform variation is a process that extends the versatility of...

The Center for Neurogenetics was featured in the American Society of Human Genetics (ASHG) Annual Meeting October 6-10, 2020.

The Center for Neurogenetics (CNG) is a translational research hub that brings together clinicians, geneticists, neuroscientists, patients and family members to seek the underlying genetic contributions to and advanced therapeutics for disorders of the nervous system.

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