News

Discovery Illuminates How Parkinson’s Disease Spreads in The Brain

image of a person with parkinson's disease at the doctor

Aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson’s disease through a cellular waste-ejection process, suggests a new study led by Weill Cornell Medicine researchers.

During the process, called lysosomal exocytosis, neurons eject protein waste they cannot break down and recycle. The discovery, published Aug. 22 in Nature Communications, could resolve one of the mysteries...

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Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease

illustration of microscopic image of microglia cells

The discovery of how to shift damaged brain cells from a diseased state into a healthy one poses a new potential path to treating Alzheimer’s and other forms of dementia, according to a new collaborative study from researchers at UC San Francisco and Weill Cornell Medicine.

The research focuses on microglia, cells that stabilize the brain by clearing out damaged neurons and the protein plaques often associated with dementia and other brain diseases.

“These cells are understudied...

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New Study Reveals Where Memory Fragments are Stored

virtual reality scene next to brain imaging

Video of behaviorImage_combine15x

As mice navigate different rooms in virtual reality, the prefrontal neurons (top) communicate with those in the hippocampus (bottom) to conjure associated memories. Video courtesy of Nakul Yadav. From Yadav, N., Noble, C., Niemeyer, J.E. et al. Prefrontal feature representations drive memory recall. Nature (2022...

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Some Autism Spectrum Disorder Symptoms Linked to Astrocytes

brain images with astrocytes labeled

Abnormalities in a type of brain cell called astrocytes may play a pivotal role in causing some behavioral symptoms of autism spectrum disorders, according to a preclinical study by Weill Cornell Medicine investigators.  

For the study, published April 1 in Molecular Psychiatry, senior author Dr. Dilek Colak,...

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Key Signaling Pathway in Immune Cells Could be New Alzheimer’s Target

microscopic images of brain slices with tau marked

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer’s and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators. The findings point to the possibility of new therapeutic strategies against neurodegenerative diseases, which are relatively common in older adults and so far have no effective, disease-modifying treatments.

Brain inflammation,...

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Delayed Recovery of Consciousness Is Common for COVID Patients on Respirators

someone on a ventilator

Most patients with severe COVID who are put on ventilators regain consciousness after removal of respiratory support, but recovery may take weeks after the period of mechanical ventilation has ended, according to a new study by investigators at Weill Cornell Medicine, Columbia University Vagelos College of Physicians and Surgeons, Harvard Medical School, NewYork-Presbyterian...

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Gut microbiota, endothelial dysfunction and tau-mediated cognitive impairment

Guiseppe Faraco

Dr. Giuseppe Faraco received a grant from Cure Alzheimer’s Fund titled “Gut microbiota, endothelial dysfunction and tau-mediated cognitive impairment”. The grant aims at elucidating the link between microbiota-induced dysregulation of gut immunity, tau pathology & cognitive impairment.

Contract Supports Research into Personalized Treatments for Depression

a man smiling for a photo

A three-year contract from Wellcome Leap will allow a team of investigators from Weill Cornell Medicine, Stanford Medicine and UC San Diego School of Medicine to study new ways to combat depression and create models that can predict which treatment is likely to work for individual patients.

“The purpose of this project is to develop new approaches to treating depression that work more effectively and in a more personalized way,” said principal investigator...

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Mapping Dementia-Linked Protein Interactions Yields Potential New Treatment Targets

Abstract illustration of a brain

By mapping all the protein interactions of a dementia-linked protein in the brain called Tau, a team of Weill Cornell Medicine investigators has created a road map for identifying potential new treatment targets for Alzheimer’s disease and related dementia.

Tau protein has long been implicated in neurodegenerative diseases. Mutations in the gene that encodes the Tau protein result in neurodegenerative...

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Academic Year 2022

Hibiki Fujita  (PI)

Muscular Dystrophy Associations of America, Inc. MDA 961871-01
Genetic and metabolic strategies for mutant CHCHD10 neuromuscular disorders

Antoine Anfray  (PI)
BrightFocus Foundation A2022003F
Role of perivascular macrophages in ApoE4-induced neurovascular dysfunction

Keith P. Purpura  (PI)
National Eye Institute 1R01EY034150-01
Role of fixational eye...

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