$9M Grant Funds Study of Gut-Brain Connection in Parkinson’s Disease

an illustration of a human brain scan

Dr. Michael Kaplitt, a professor of neurological surgery at Weill Cornell Medicine and a longtime leader in developing cutting-edge surgical therapies for movement disorders, leads a team that has been awarded a three-year, $8.9 million grant from the Aligning Science Across Parkinson’s (ASAP) initiative. The grant will fund an...

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Structural and Functional Alignment in the Brain Linked to Age, Sex and Cognition

brain images with color waves

The degree to which the brain’s wiring aligns with its patterns of activity can vary with sex and age, and may be genetic, suggests a study published by Weill Cornell Medicine investigators. The study finds that this alignment may also have implications on cognition.

The results published July 12 in Nature Communications help shed light on one of the biggest mysteries in biology—how the brain works, according to senior...

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Study Finds High Blood Pressure Linked to Loss of Estrogen in Peri-menopause

estrogen receptor under microscope

Women become more susceptible to hypertension as they approach menopause, and now a preclinical study led by researchers at Weill Cornell Medicine’s Feil Family Brain and Mind Research Institute suggests that this “perimenopausal” hypertension may be driven by declines in estrogen signaling in a brain region called the hypothalamus—and may be preventable with estrogen-like treatments.

In the...

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Dr. Giovanni Manfredi Awarded NIH Outstanding Investigator Award

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Dr. Giovanni Manfredi, the Finbar and Marianne Kenny Professor in Clinical and Research Neurology at Weill Cornell Medicine’s Feil Family Brain and Mind Research Institute, has received an Outstanding Investigator Award (R35) from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS) to study the role of mitochondrial dysfunction in brain disease.

The highly competitive award...

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Prefrontal Cortex of Brain Provides Feedback to Redirect Attention

brain showing flurorescent prefrontal cortex cells

To enable animals to shift their attention in response to changing circumstances, the prefrontal cortex of the brain helps keep track of which types of stimuli have recently been most relevant, suggests a preclinical study by Weill Cornell Medicine and NewYork-Presbyterian investigators. This discovery could lead to new treatments to help restore cognitive flexibility.

“Animals and people make split-second decisions about what to do in changing circumstances and what to pay attention...

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Salt Sense: Scientists at the Feil Family Brain and Mind Research Institute Investigate the Link Between a High-Sodium Diet and Dementia

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On its face, the logic seems straightforward. Eating too much salt can lead to high blood pressure; numerous studies have shown that having hypertension in midlife makes it more likely that you’ll develop certain forms of dementia, including Alzheimer’s disease, in later years. Therefore, overly high sodium intake puts some people at risk of future cognitive impairment.

Study Brings Neuroscience a Step Closer to a High-Resolution Mammalian Brain Atlas

illustration of cells in the body

A team led by scientists at Weill Cornell Medicine has made a map identifying all the different RNA molecules that are derived from each gene in the brains of mice. It is the first map that depicts this important layer of biological diversity, called isoform variation, by cell type and across brain regions for the whole genome, and it contributes to neuroscientists’ ambitious goal of an ultra-detailed atlas of the brain.

Isoform variation is a process that extends the versatility of...

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Center for Neurogenetics at Weill Cornell

CNG Video image

The Center for Neurogenetics was featured in the American Society of Human Genetics (ASHG) Annual Meeting October 6-10, 2020.

The Center for Neurogenetics (CNG) is a translational research hub that brings together clinicians, geneticists, neuroscientists, patients and family members to seek the underlying genetic contributions to and advanced therapeutics for disorders of the nervous system.


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Alzheimer’s-Related Tau Protein Can Disrupt Blood Flow in the Brain, Long Before Neurodegeneration Sets In

image of cells

Abnormal forms of a brain-cell protein called tau, which have long been implicated in Alzheimer’s and other neurodegenerative disorders, may contribute to neurodegeneration earlier than was previously understood, by interfering with the normal dynamics of blood flow in the brain, suggests a study from scientists at Weill Cornell Medicine. The results pave the way for research efforts that seek to prevent early neurodegeneration by restoring normal blood flow.

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