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Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer’s and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators. The findings point to the possibility of new therapeutic strategies against neurodegenerative diseases, which are relatively common in older adults and so far have no effective, disease-modifying treatments.

Brain inflammation,...

Dr. Giuseppe Faraco received a grant from Cure Alzheimer’s Fund titled “Gut microbiota, endothelial dysfunction and tau-mediated cognitive impairment”. The grant aims at elucidating the link between microbiota-induced dysregulation of gut immunity, tau pathology & cognitive impairment.

By mapping all the protein interactions of a dementia-linked protein in the brain called Tau, a team of Weill Cornell Medicine investigators has created a road map for identifying potential new treatment targets for Alzheimer’s disease and related dementia.

Tau protein has long been implicated in neurodegenerative diseases. Mutations in the gene that encodes the Tau protein result in neurodegenerative...

Multiple changes in brain cells during the first month of embryonic development may contribute to schizophrenia later in life, according to a new study by Weill Cornell Medicine investigators.

The researchers, whose study was published in Molecular Psychiatry on Nov. 17, used stem cells collected from patients with schizophrenia and people without the disease to grow 3-dimensional “mini-brains” or organoids in the...