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Rewired

June 17, 2025

Neurologist Dr. Nicholas Schiff (M.D. ’92) has pioneered the use of deep brain stimulation in people with traumatic brain injury, helping them regain lost cognitive and motor skills. In parallel, he has worked to identify impaired patients with hidden cognitive function and is now seeking to test brain-computer interfaces that might help them.

Dr. Teresa Sanchez Awarded the Established Investigator Award from the American Heart Association

June 12, 2025

Dr. Teresa Sanchez, associate professor of pathology and laboratory medicine and associate professor of neuroscience in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine, has been awarded the highly competitive Established Investigator Award from the American Heart Association.

The five-year, $550,000 grant supports mid-career...

June 5, 2025

At the 12th annual Helen and Robert Appel Alzheimer’s Disease Research Institute Symposium, scientists and clinicians shared their latest research which is advancing how Alzheimer’s disease is diagnosed and treated. Held at Weill Cornell Medicine’s Griffis Faculty Club, the...

February 14, 2025

Weill Cornell Medicine researchers have found that intracranial hemorrhages, or "brain bleeds" caused by a ruptured blood vessel in the brain, double a person’s risk of developing dementia later in life.

While the connection between dementia and ischemic strokes caused by clots that block blood supply to the brain has received more attention, the...

December 19, 2024

Neuroscientist Dr. Gary Gibson keeps a framed picture of a cell derived from the skin cells of a person with Alzheimer’s disease on his office wall.

The image is a memento of Dr. Gibson’s breakthrough hypothesis about an underlying cause of mild cognitive impairment and Alzheimer’s – that an insufficiency of vitamin B1 called thiamine...

December 2, 2024

Increasing the levels of chemicals naturally produced in the body called endocannabinoids may thwart the highly addictive nature of opioids such as morphine and oxycodone while maintaining the drugs’ ability to relieve pain, according to Weill Cornell Medicine investigators working with researchers from The Center for Youth Mental Health at NewYork-...

image of neurons in the brain stained for myelin

November 28, 2024

Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer’s disease and ordinary aging, suggests a study led by researchers at Weill Cornell Medicine.

Most nerve fibers in vertebrates are encased in sheaths made largely of a protein called myelin, which protects the fibers and greatly enhances the efficiency of their signal...

inflammatory microglia stained green and yellow

September 30, 2024

Weill Cornell Medicine investigators have found that two genetic variants that confer high risk of Alzheimer’s disease (AD) together trigger a harmful inflammatory response in the brain’s immune cells, particularly in females, in a preclinical model.

The findings, published Sept. 30 in Neuron, emphasize the importance of considering sex...

September 18, 2024

A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer’s disease—increases the risk of neurodegeneration and white matter damage. Researchers at Weill Cornell Medicine discovered that immune cells in the brain called border-associated macrophages (BAMs) are a source of ApoE4 protein and contribute to damaging blood vessels and brain tissue.

Brain Scanning Approach Shows Wiring of Depression

September 4, 2024

By repeatedly scanning the brains of a small group of patients for a year and a half, Weill Cornell Medicine researchers have identified a distinct pattern of neuronal interactions that appears to predispose some people to developing depression.

Published Sept. 4 in Nature, the work highlights the potential...

Rewired

Dr. Teresa Sanchez Awarded the Established Investigator Award from the American Heart Association

Looking Beyond Beta-Amyloid: New Paths in Alzheimer's Research

Brain Bleeds Increase the Risk of Dementia

Decades of Work Leads to Clinical Trial for Early Alzheimer’s Treatment

Reducing Risk of Opioid Addiction While Alleviating Pain

Sex Differences in Neuron Protection Reveal Potential Alzheimer's Target

Alzheimer’s Genetic Risk Factors Spark Inflammation in Females

Brain Macrophages with ApoE4 Play a Key Role in Damaging Blood Vessels and Neurodegeneration

Brain Scanning Approach Shows Wiring of Depression