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News

Mapping Dementia-Linked Protein Interactions Yields Potential New Treatment Targets

Abstract illustration of a brain

By mapping all the protein interactions of a dementia-linked protein in the brain called Tau, a team of Weill Cornell Medicine investigators has created a road map for identifying potential new treatment targets for Alzheimer’s disease and related dementia.

Tau protein has long been implicated in neurodegenerative diseases. Mutations in the gene that encodes the Tau protein result in neurodegenerative...

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“Mini-Brains” Provide Clues About Early Life Origins of Schizophrenia

microscopic image mini brian

Multiple changes in brain cells during the first month of embryonic development may contribute to schizophrenia later in life, according to a new study by Weill Cornell Medicine investigators.

The researchers, whose study was published in Molecular Psychiatry on Nov. 17, used stem cells collected from patients with schizophrenia and people without the disease to grow 3-dimensional “mini-brains” or organoids in the...

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Researchers Develop New Approach to Analyzing Complex Genetics Underlying Spina Bifida

Dr. Elizabeth Ross

Weill Cornell Medicine researchers are using machine learning, a form of artificial intelligence, to shed light on genetic mutations associated with spina bifida. In this birth defect, the neural tube that forms the spinal cord during pregnancy, does not close so that spinal nerves are exposed, resulting in paralysis and high risk of other complications.

Their new study, published online Dec. 16 in PNAS, “brings us closer to...

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Novel Immune Cell Population May Trigger Inflammation in Multiple Sclerosis and other Brain Disorders

Inflammatory immune cells in the spinal cord of mouse

A group of immune cells that normally protect against inflammation in the gastrointestinal tract may have the opposite effect in multiple sclerosis (MS) and other brain inflammation-related conditions, according to a new study by Weill Cornell Medicine and NewYork-Presbyterian researchers. The results suggest that countering the activity of these cells could be a new therapeutic approach for such conditions.

The...

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Targeting the Brain’s Immune Cells May Help Prevent or Treat Alzheimer’s Disease

multicolor dots representing different microglial cell states

A gene mutation linked to Alzheimer’s disease alters a signaling pathway in certain immune cells of individuals with the disease, according to a new study by scientists at Weill Cornell Medicine. The team also found that blocking the pathway—with a drug that’s currently being tested in cancer clinical trials—protects against many features of the condition in a preclinical model. The results could lead to new strategies to...

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Department of Defense Funds Research on Rare Eye Condition

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Weill Cornell Medicine has received a $1.27 million grant from the United States Department of Defense (DoD) to develop treatment for a rare but devastating eye condition largely affecting military personnel who suffer traumatic eye injuries in combat.

Under the three-year grant, investigators will test the safety and effectiveness of two newly developed antibodies to treat proliferative vitreoretinopathy, or PVR. Currently not treatable or preventable,...

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Annual Appel Alzheimer's Disease Research Institute Symposium Highlights Latest Research in Dementia

brain illustration

Some of the latest research discoveries in neurodegenerative disease and their potential therapeutic applications were featured at the ninth annual Appel Alzheimer's Disease Research Institute Symposium, held remotely on Nov. 9. 

Sponsored by Weill Cornell Medicine’s Helen and Robert Appel Alzheimer’s Disease Research Institute and its home department, the Feil Family Brain...

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Dr. Costantino Iadecola Wins the American Heart Association’s 2021 Basic Research Prize

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Dr. Costantino Iadecola, director and chair of the Feil Family Brain and Mind Research Institute and the Anne Parrish Titzell Professor of Neurology at Weill Cornell Medicine, has been awarded the 2021 Basic Research Prize from the American Heart Association (AHA).

The AHA Basic Research Prize is given annually to an individual in recognition...

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$9M Grant Funds Study of Gut-Brain Connection in Parkinson’s Disease

an illustration of a human brain scan

Dr. Michael Kaplitt, a professor of neurological surgery at Weill Cornell Medicine and a longtime leader in developing cutting-edge surgical therapies for movement disorders, leads a team that has been awarded a three-year, $8.9 million grant from the Aligning Science Across Parkinson’s (ASAP) initiative. The grant will fund an...

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Structural and Functional Alignment in the Brain Linked to Age, Sex and Cognition

brain images with color waves

The degree to which the brain’s wiring aligns with its patterns of activity can vary with sex and age, and may be genetic, suggests a study published by Weill Cornell Medicine investigators. The study finds that this alignment may also have implications on cognition.

The results published July 12 in Nature Communications help shed light on one of the biggest mysteries in biology—how the brain works, according to senior...

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