Commercial Astronauts Shed Light on Flights’ Health Impacts and Create Spaceflight Atlas

picture of earth from space

Short-term space travel causes many of the same molecular and physiologic changes as long-term space missions, but most reverse within months of returning to Earth. Yet, those changes that are longer-lasting and distinct between crew members reveal new targets for aerospace medicine and can guide new missions, according to the results of a massive international research endeavor by investigators at Weill Cornell Medicine,...

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Astrocytes Induce Sex-Specific Effects on Memory

Anna Orr astrocytes

Weill Cornell Medicine scientists have uncovered the first evidence that astrocyte receptors can trigger opposite effects on cognitive function in male and female preclinical models. The findings point to astrocytes, brain cells that support and regulate neurons, as key contributors to sex-specific brain mechanisms.

While many studies have tested the behavioral effects of astrocytic receptors, none of them have addressed whether biological sex plays a role and most have tested only...

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New Atlas of mRNA Variants Captures Inner Workings of the Brain

mRNA isoforms

Investigators at Weill Cornell Medicine have assembled the most comprehensive atlas to date of messenger RNA (mRNA) variants in the mouse and human brain. The atlas is an important new resource in understanding brain development, neuron specialization and other brain functions.

RNA transcripts that are copied from DNA sequences carry the instructions for building proteins and show which genes are active in a...

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Apixaban No Better Than Aspirin for Preventing Stroke Recurrence in Patients with Atrial Cardiopathy

illustration of blood vessels leading to the brain

More than a decade ago, the anticoagulant apixaban, trade name Eliquis, was shown to be superior to aspirin for preventing recurrent stroke in patients with a heart condition called atrial fibrillation. But a multi-center, phase 3 clinical trial has found that apixaban is no more effective than aspirin at preventing a second stroke in patients diagnosed with a milder, related condition called atrial cardiopathy, according to results reported by researchers at Weill Cornell Medicine, Columbia...

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Mapping Brain Repair and Remodelling After Stroke

immune cells infiltrate brain after stroke

Researchers at Weill Cornell Medicine have painstakingly catalogued the cellular response to stroke in a preclinical model, identifying the immune cells involved and the roles they may play in the days and weeks following a stroke. During a stroke, loss of oxygen leads to brain damage and cell death. It also triggers a powerful inflammatory response in which the brain’s resident immune cells, along with cells...

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Immune Protein May Induce Dementia Unrelated to High Blood Pressure

connection between high blood pressure and dementia

Researchers at Weill Cornell Medicine have found that controlling high blood pressure may not be enough to prevent associated cognitive declines. The findings point to an immune protein called cytokine IL-17 as a culprit for inducing dementia and suggest new approaches to prevent damage to brain cells.

The study, published on Dec. 4 in Nature Neuroscience, uncovered a new mechanism...

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Deep Brain Stimulation Improves Cognition During Chronic Recovery Phase of Brain Injury

image of brain with electrode and nerve fibers

Five people who had life-altering, seemingly irreversible cognitive deficits following moderate to severe traumatic brain injuries showed substantial improvements in their cognition and quality of life after receiving an experimental form of deep brain stimulation (DBS) in a phase 1 clinical trial. The trial, reported Dec. 4 in Nature Medicine, was led by investigators at Weill Cornell Medicine, Stanford University, the...

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Appel Alzheimer's Disease Research Institute Symposium Highlights Progress Towards New Treatments

Alzheimer's disease symposium

The 11th annual Appel Alzheimer's Disease Research Institute Symposium brought together leading scientists and clinicians in the field to present the latest advances in understanding Alzheimer’s and related neurodegenerative diseases. The event was held at the Belfer Research Building on Nov. 9.

Helen and Robert Appel established the Institute in 2006 after they lost close friends to Alzheimer’s. “I am hopeful that we are closer than ever...

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Scientists Use A.I.-Generated Images to Map Visual Functions in the Brain

Generative AI illustration of a chihuahua

Researchers at Weill Cornell Medicine, Cornell Tech and Cornell's Ithaca campus have demonstrated the use of AI-selected natural images and AI-generated synthetic images as neuroscientific tools for probing the visual processing areas of the brain. The goal is to apply a data-driven approach to understand how vision is organized while potentially removing biases that may arise when looking at responses to a more limited set of researcher-selected images.

In the...

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Awards and Honors: July 2023

Three white trophies against a red backdrop

Dr. James Bussel, professor emeritus of pediatrics, was awarded the Henry M. Stratton Medal from the American Society of Hematology (ASH). The award seeks to recognize individuals who have made outstanding contributions to hematology. Dr. Bussel, the recipient of the medal for translational/clinical science, is being honored for his contributions to the development of agents that increase platelet counts in...

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