Feil Family Brain & Mind Research Institute

Publications

Found 16 results
Author Title Type [ Year(Desc)]
Filters: Keyword is Amyloid beta-Peptides  [Clear All Filters]
2014
Park L, Wang G, Moore J, Girouard H, Zhou P, Anrather J, Iadecola C.  2014.  The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction.. Nat Commun. 5:5318.
Hu X, Li X, Zhao M, Gottesdiener A, Luo W, Paul S.  2014.  Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.. Mol Neurodegener. 9:52.
Ishii M, Wang G, Racchumi G, Dyke JP, Iadecola C.  2014.  Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.. J Neurosci. 34(27):9096-106.
2015
Ishii M, Iadecola C.  2015.  Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.. Cell Metab. 22(5):761-76.
2016
Koizumi K, Wang G, Park L.  2016.  Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations.. Cell Mol Neurobiol. 36(2):155-65.
Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG et al..  2016.  Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.. Neurobiol Aging. 44:159-172.
Yuan P, Condello C, C Keene D, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J.  2016.  TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.. Neuron. 90(4):724-39.
2017
Kawamata H, Manfredi G.  2017.  Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.. J Cell Biol. 216(12):3917-3929.
2022
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK et al..  2022.  Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.. Mol Neurodegener. 17(1):41.
2023
Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu G-Q, Yu X, Smith N et al..  2023.  Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.. Neurobiol Dis. 186:106263.
Uekawa K, Hattori Y, Ahn SJi, Seo J, Casey N, Anfray A, Zhou P, Luo W, Anrather J, Park L et al..  2023.  Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.. Mol Neurodegener. 18(1):73.
Eruysal E, Ravdin L, Zhang C, Kamel H, Iadecola C, Ishii M.  2023.  Sexually Dimorphic Association of Circulating Plasminogen Activator Inhibitor-1 Levels and Body Mass Index with Cerebrospinal Fluid Biomarkers of Alzheimer's Pathology in Preclinical Alzheimer's Disease.. J Alzheimers Dis. 91(3):1073-1083.
Evering TH, Marston JL, Gan L, Nixon DF.  2023.  Transposable elements and Alzheimer's disease pathogenesis.. Trends Neurosci. 46(3):170-172.
2024
Santisteban MM, Iadecola C.  2024.  A deeper dive into amyloid clearance by meningeal lymphatic vessels.. Nat Cardiovasc Res. 3(4):407-409.
Uekawa K, Anfray A, Ahn SJi, Casey N, Seo J, Zhou P, Iadecola C, Park L.  2024.  tPA supplementation preserves neurovascular and cognitive function in Tg2576 mice.. Alzheimers Dement. 20(7):4572-4582.
Qu W, Lam M, McInvale JJ, Mares JA, Kwon S, Humala N, Mahajan A, Nguyen T, Jakubiak KA, Mun J-Y et al..  2024.  Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.. Acta Neuropathol. 147(1):107.