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Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.

TitleMetabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.
Publication TypeJournal Article
Year of Publication2015
AuthorsIshii M, Iadecola C
JournalCell Metab
Volume22
Issue5
Pagination761-76
Date Published2015 Nov 03
ISSN1932-7420
KeywordsAlzheimer Disease, Amyloid beta-Peptides, Animals, Biomarkers, Body Weight, Cognition, Disease Models, Animal, Humans, Hypothalamus, Neuroendocrine Cells
Abstract

Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative disease beginning decades prior to the cognitive decline. While cognitive deficits remain the cardinal manifestation of AD, metabolic and non-cognitive abnormalities, such as alterations in body weight and neuroendocrine functions, are also present, often preceding the cognitive decline. Furthermore, hypothalamic dysfunction can also be a driver of AD pathology. Here we offer a brief appraisal of hypothalamic dysfunction in AD and provide insight into an underappreciated dual role of the hypothalamus as both a culprit and target of AD pathology, as well as into new opportunities for therapeutic interventions and biomarker development.

DOI10.1016/j.cmet.2015.08.016
Alternate JournalCell Metab.
PubMed ID26365177
PubMed Central IDPMC4654127
Grant ListR01 NS037853 / NS / NINDS NIH HHS / United States
NS37853 / NS / NINDS NIH HHS / United States