New Atlas of mRNA Variants Captures Inner Workings of the Brain

mRNA isoforms

Investigators at Weill Cornell Medicine have assembled the most comprehensive atlas to date of messenger RNA (mRNA) variants in the mouse and human brain. The atlas is an important new resource in understanding brain development, neuron specialization and other brain functions.

RNA transcripts that are copied from DNA sequences carry the instructions for building proteins and show which genes are active in a...

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Apixaban No Better Than Aspirin for Preventing Stroke Recurrence in Patients with Atrial Cardiopathy

illustration of blood vessels leading to the brain

More than a decade ago, the anticoagulant apixaban, trade name Eliquis, was shown to be superior to aspirin for preventing recurrent stroke in patients with a heart condition called atrial fibrillation. But a multi-center, phase 3 clinical trial has found that apixaban is no more effective than aspirin at preventing a second stroke in patients diagnosed with a milder, related condition called atrial cardiopathy, according to results reported by researchers at Weill Cornell Medicine, Columbia...

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Mapping Brain Repair and Remodelling After Stroke

immune cells infiltrate brain after stroke

Researchers at Weill Cornell Medicine have painstakingly catalogued the cellular response to stroke in a preclinical model, identifying the immune cells involved and the roles they may play in the days and weeks following a stroke. During a stroke, loss of oxygen leads to brain damage and cell death. It also triggers a powerful inflammatory response in which the brain’s resident immune cells, along with cells...

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Immune Protein May Induce Dementia Unrelated to High Blood Pressure

connection between high blood pressure and dementia

Researchers at Weill Cornell Medicine have found that controlling high blood pressure may not be enough to prevent associated cognitive declines. The findings point to an immune protein called cytokine IL-17 as a culprit for inducing dementia and suggest new approaches to prevent damage to brain cells.

The study, published on Dec. 4 in Nature Neuroscience, uncovered a new mechanism...

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Deep Brain Stimulation Improves Cognition During Chronic Recovery Phase of Brain Injury

image of brain with electrode and nerve fibers

Five people who had life-altering, seemingly irreversible cognitive deficits following moderate to severe traumatic brain injuries showed substantial improvements in their cognition and quality of life after receiving an experimental form of deep brain stimulation (DBS) in a phase 1 clinical trial. The trial, reported Dec. 4 in Nature Medicine, was led by investigators at Weill Cornell Medicine, Stanford University, the...

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Appel Alzheimer's Disease Research Institute Symposium Highlights Progress Towards New Treatments

Alzheimer's disease symposium

The 11th annual Appel Alzheimer's Disease Research Institute Symposium brought together leading scientists and clinicians in the field to present the latest advances in understanding Alzheimer’s and related neurodegenerative diseases. The event was held at the Belfer Research Building on Nov. 9.

Helen and Robert Appel established the Institute in 2006 after they lost close friends to Alzheimer’s. “I am hopeful that we are closer than ever...

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Scientists Use A.I.-Generated Images to Map Visual Functions in the Brain

Generative AI illustration of a chihuahua

Researchers at Weill Cornell Medicine, Cornell Tech and Cornell's Ithaca campus have demonstrated the use of AI-selected natural images and AI-generated synthetic images as neuroscientific tools for probing the visual processing areas of the brain. The goal is to apply a data-driven approach to understand how vision is organized while potentially removing biases that may arise when looking at responses to a more limited set of researcher-selected images.

In the...

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Awards and Honors: July 2023

Three white trophies against a red backdrop

Dr. James Bussel, professor emeritus of pediatrics, was awarded the Henry M. Stratton Medal from the American Society of Hematology (ASH). The award seeks to recognize individuals who have made outstanding contributions to hematology. Dr. Bussel, the recipient of the medal for translational/clinical science, is being honored for his contributions to the development of agents that increase platelet counts in...

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Key bacteria in onset and progression of MS identified

JCI cover May 2023

In a recent animal study, researchers from the Brain and Mind Research Institute at Weill Cornell Medicine have found that epsilon toxin — produced by a bacterium found in the small intestine — may trigger the onset of MS and cause continuing symptoms. The study is published in The Journal of Clinical Investigation, ...

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Astrocyte Dysfunction Causes Cognitive Decline

microscopic illustration

People with dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss, according to a preclinical study by a team of Weill Cornell Medicine investigators.

Dysfunction in cells called neurons, which transmit messages throughout the brain, has long been the prime suspect in dementia-related cognitive deficits. But a new...

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