Publications

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2025

Khawaja RR, Griego E, Lindenau K, Salek A, Gambardella J, Scrivo A, Monday HR, Bourdenx M, Madero-Pérez J, Khan ZN et al.. 2025. Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.. Nat Cell Biol. 27(10):1688-1707.

Hu W, Foord C, Hsu J, Fan L, Corley MJ, Lanjewar SN, Xu S, Belchikov N, He Y, Pang APS et al.. 2025. Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state.. Nat Biotechnol.

Chen H, Fan L, Guo Q, Wong MYing, Zhu J, Foxe N, Wang W, Nessim A, Carling G, Liu B et al.. 2025. DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice.. Mol Neurodegener. 20(1):124.

Wang Z, Lipshutz A, de la Torre CMartínez, Trzeciak AJ, Liu Z-L, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A et al.. 2025. Early life high fructose impairs microglial phagocytosis and neurodevelopment.. Nature.

Alarcón-Espósito J, Nagiri RKumar, Wang S, Larson C, Carvallo-Torres L, Singh VKumar, J Glickman F, Gan L, Sinha SC. 2025. High-Throughput Screening and Initial SAR Studies Identify a Novel Submicromolar Potent Human cGAS Inhibitor.. ACS Chem Biol. 20(12):2886-2896.

Wang S, Qi C, Rajpurohit C, Ghosh B, Xiong W, Wang B, Qi Y, Hwang SHee, Hammock BD, Li H et al.. 2025. Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model.. Mol Neurodegener. 20(1):44.

Barnett D, Zimmer TS, Booraem C, Palaguachi F, Meadows SM, Xiao H, Wong MYing, Luo W, Gan L, Chouchani ET et al.. 2025. Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.. Nat Metab. 7(11):2300-2323.

Clelland CDudley, Fan L, Saloner R, Etchegaray JIker, Altobelli CRichard, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee S-I et al.. 2025. Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.. Commun Biol. 8(1):971.

Naguib S, Lopez-Lee C, Torres ERuth, Lee S-I, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MYing et al.. 2025. The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.. Immunity.

Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV et al.. 2025. REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis.. Nat Aging.

Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S et al.. 2025. A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.. Cell Rep. 44(9):116198.

2024

Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MYing, Zhu D, Yu F, Xu J, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. bioRxiv.

Carling GK, Fan L, Foxe NR, Norman K, Wong MYing, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. Neuron.

Bravo CParra, Krukowski K, Barker S, Wang C, Li Y, Fan L, Vázquez-Rosa E, Shin M-K, Wong MYing, McCullough LD et al.. 2024. Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.. Mol Neurodegener. 19(1):51.

Cheng F, Wang F, Tang J, Zhou Y, Fu Z, Zhang P, Haines JL, Leverenz JB, Gan L, Hu J et al.. 2024. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.. Cell Rep Med. 5(2):101379.

Bravo CParra, Giani AMaria, Perez JMadero, Zhao Z, Wan Y, Samelson AJ, Wong MYing, Evangelisti A, Cordes E, Fan L et al.. 2024. Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.. Cell.

Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R et al.. 2024. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.. Mol Cell Neurosci. 130:103954.

Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y et al.. 2024. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. J Clin Invest. 134(3)

Lopez-Lee C, Torres ERuth S, Carling G, Gan L. 2024. Mechanisms of sex differences in Alzheimer's disease.. Neuron.

Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR et al.. 2024. Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.. PNAS Nexus. 3(5):pgae179.

Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MBukar, Clelland CD, Cohen AD, Crary JF, Dage JL et al.. 2024. Novel avenues of tau research.. Alzheimers Dement.

Lopez-Lee C, Kodama L, Fan L, Zhu D, Zhu J, Wong MYing, Ye P, Norman K, Foxe NR, Ijaz L et al.. 2024. Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.. Science. 386(6725):eadk7844.

2023

Luo W, Qu W, Gan L. 2023. The AD odyssey 2023: Tales of single cell.. Cell. 186(20):4257-4259.

Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu G-Q, Yu X, Smith N et al.. 2023. Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.. Neurobiol Dis. 186:106263.

Amin S, Liu B, Gan L. 2023. Autophagy prevents microglial senescence.. Nat Cell Biol. 25(7):923-925.