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A
Luo W
,
Qu W
,
Gan L
. 2023.
The AD odyssey 2023: Tales of single cell.
.
Cell. 186(20):4257-4259.
Das M
,
Mao W
,
Voskobiynyk Y
,
Necula D
,
Lew I
,
Petersen C
,
Zahn A
,
Yu G-Q
,
Yu X
,
Smith N
et al.
. 2023.
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
.
Neurobiol Dis. 186:106263.
Carling GK
,
Fan L
,
Foxe NR
,
Norman K
,
Ye P
,
Wong MYing
,
Zhu D
,
Yu F
,
Xu J
,
Yarahmady A
et al.
. 2024.
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
.
bioRxiv.
Carling GK
,
Fan L
,
Foxe NR
,
Norman K
,
Wong MYing
,
Zhu D
,
Corona C
,
Razzoli A
,
Yu F
,
Yarahmady A
et al.
. 2024.
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
.
Neuron.
Bravo CParra
,
Krukowski K
,
Barker S
,
Wang C
,
Li Y
,
Fan L
,
Vázquez-Rosa E
,
Shin M-K
,
Wong MYing
,
McCullough LD
et al.
. 2024.
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.
.
Mol Neurodegener. 19(1):51.
Han L
,
Gan L
. 2022.
The Application of Artificial Neural Network Combined with Virtual Reality Technology in Environment Art Design.
.
Comput Intell Neurosci. 2022:7562167.
Cheng F
,
Wang F
,
Tang J
,
Zhou Y
,
Fu Z
,
Zhang P
,
Haines JL
,
Leverenz JB
,
Gan L
,
Hu J
et al.
. 2024.
Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.
.
Cell Rep Med. 5(2):101379.
Amin S
,
Liu B
,
Gan L
. 2023.
Autophagy prevents microglial senescence.
.
Nat Cell Biol. 25(7):923-925.
C
Gan L
,
Cookson MR
,
Petrucelli L
,
La Spada AR
. 2018.
Converging pathways in neurodegeneration, from genetics to mechanisms.
.
Nat Neurosci. 21(10):1300-1309.
Samelson AJ
,
Ariqat N
,
McKetney J
,
Rohanitazangi G
,
Bravo CParra
,
Goodness D
,
Tian R
,
Grosjean P
,
Abskharon R
,
Eisenberg D
et al.
. 2023.
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
.
bioRxiv.
Dräger NM
,
Sattler SM
,
Huang CTzu-Ling
,
Teter OM
,
Leng K
,
Hashemi SHadi
,
Hong J
,
Aviles G
,
Clelland CD
,
Zhan L
et al.
. 2022.
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
.
Nat Neurosci.
D
Chen H
,
Fan L
,
Guo Q
,
Wong MYing
,
Yu F
,
Foxe N
,
Wang W
,
Nessim A
,
Carling G
,
Liu B
et al.
. 2023.
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
.
bioRxiv.
Chen H
,
Fan L
,
Guo Q
,
Wong MYing
,
Yu F
,
Foxe N
,
Wang W
,
Nessim A
,
Carling G
,
Liu B
et al.
. 2023.
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
.
Res Sq.
Telpoukhovskaia MA
,
Liu K
,
Sayed FA
,
Etchegaray JIker
,
Xie M
,
Zhan L
,
Li Y
,
Zhou Y
,
Le D
,
Bahr BA
et al.
. 2020.
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
.
Sci Rep. 10(1):13688.
E
Wang Z
,
Lipshutz A
,
Liu Z-L
,
Trzeciak AJ
,
Miranda IC
,
de la Torre CMartínez
,
Schild T
,
Lazarov T
,
Rojas WSaitz
,
Saavedra PHV
et al.
. 2023.
Early life high fructose exposure disrupts microglia function and impedes neurodevelopment.
.
bioRxiv.
Chen X
,
Gan L
. 2019.
An exercise-induced messenger boosts memory in Alzheimer's disease.
.
Nat Med. 25(1):20-21.
F
Dong Q
,
Gentry NW
,
McMahon T
,
Yamazaki M
,
Benitez-Rivera L
,
Wang T
,
Gan L
,
Ptáček L
,
Fu Y-H
. 2022.
Familial natural short sleep mutations reduce Alzheimer pathology in mice.
.
iScience. 25(4):103964.
Yang X
,
Wen J
,
Yang H
,
Jones IR
,
Zhu X
,
Liu W
,
Li B
,
Clelland CD
,
Luo W
,
Wong MYing
et al.
. 2023.
Functional characterization of Alzheimer's disease genetic variants in microglia.
.
Nat Genet. 55(10):1735-1744.
G
Sziraki A
,
Lu Z
,
Lee J
,
Banyai G
,
Anderson S
,
Abdulraouf A
,
Metzner E
,
Liao A
,
Banfelder J
,
Epstein A
et al.
. 2023.
A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains.
.
Nat Genet.
H
Bravo CParra
,
Giani AMaria
,
Perez JMadero
,
Zhao Z
,
Samelson A
,
Wong MYing
,
Evangelisti A
,
Fan L
,
Pozner T
,
Mercedes M
et al.
. 2023.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
bioRxiv.
Bravo CParra
,
Giani AMaria
,
Perez JMadero
,
Zhao Z
,
Wan Y
,
Samelson AJ
,
Wong MYing
,
Evangelisti A
,
Cordes E
,
Fan L
et al.
. 2024.
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
.
Cell.
I
Theofilas P
,
Wang C
,
Butler D
,
Morales DO
,
Petersen C
,
Ambrose A
,
Chin B
,
Yang T
,
Khan S
,
Ng R
et al.
. 2024.
iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.
.
Mol Cell Neurosci. 130:103954.
K
Kauwe G
,
Pareja-Navarro KA
,
Yao L
,
Chen JH
,
Wong I
,
Saloner R
,
Cifuentes H
,
Nana AL
,
Shah S
,
Li Y
et al.
. 2023.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
.
bioRxiv.
Kauwe G
,
Pareja-Navarro KA
,
Yao L
,
Chen JH
,
Wong I
,
Saloner R
,
Cifuentes H
,
Nana AL
,
Shah S
,
Li Y
et al.
. 2024.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
.
J Clin Invest. 134(3)
M
Song M
,
Yang X
,
Ren X
,
Maliskova L
,
Li B
,
Jones IR
,
Wang C
,
Jacob F
,
Wu K
,
Traglia M
et al.
. 2019.
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
.
Nat Genet. 51(8):1252-1262.
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