Toward an understanding of glucose metabolism in radial glial biology and brain development.

TitleToward an understanding of glucose metabolism in radial glial biology and brain development.
Publication TypeJournal Article
Year of Publication2024
AuthorsAndrews MG, Pearson CA
JournalLife Sci Alliance
Date Published2024 Jan
KeywordsBiology, Brain, Cell Differentiation, Glucose, Neurons

Decades of research have sought to determine the intrinsic and extrinsic mechanisms underpinning the regulation of neural progenitor maintenance and differentiation. A series of precise temporal transitions within progenitor cell populations generates all the appropriate neural cell types while maintaining a pool of self-renewing progenitors throughout embryogenesis. Recent technological advances have enabled us to gain new insights at the single-cell level, revealing an interplay between metabolic state and developmental progression that impacts the timing of proliferation and neurogenesis. This can have long-term consequences for the developing brain's neuronal specification, maturation state, and organization. Furthermore, these studies have highlighted the need to reassess the instructive role of glucose metabolism in determining progenitor cell division, differentiation, and fate. This review focuses on glucose metabolism (glycolysis) in cortical progenitor cells and the emerging focus on glycolysis during neurogenic transitions. Furthermore, we discuss how the field can learn from other biological systems to improve our understanding of the spatial and temporal changes in glycolysis in progenitors and evaluate functional neurological outcomes.

Alternate JournalLife Sci Alliance
PubMed ID37798120
PubMed Central IDPMC10556723
Grant ListR00 MH125329 / MH / NIMH NIH HHS / United States