For COVID-19 vaccine updates, please review our information guide and sign up for Connect. Continue your routine care with us by scheduling an in-person appointment or Video Visit.

Structural connectome disruption at baseline predicts 6-months post-stroke outcome.

TitleStructural connectome disruption at baseline predicts 6-months post-stroke outcome.
Publication TypeJournal Article
Year of Publication2016
AuthorsKuceyeski A, Navi BB, Kamel H, Raj A, Relkin N, Toglia J, Iadecola C, O'Dell M
JournalHum Brain Mapp
Date Published2016 07
KeywordsAged, Brain, Brain Ischemia, Connectome, Diffusion Magnetic Resonance Imaging, Female, Follow-Up Studies, Humans, Image Interpretation, Computer-Assisted, Least-Squares Analysis, Male, Prognosis, Stroke, Stroke Rehabilitation, Treatment Outcome

In this study, models based on quantitative imaging biomarkers of post-stroke structural connectome disruption were used to predict six-month outcomes in various domains. Demographic information and clinical MRIs were collected from 40 ischemic stroke subjects (age: 68.1 ± 13.2 years, 17 female, NIHSS: 6.8 ± 5.6). Diffusion-weighted images were used to create lesion masks, which were uploaded to the Network Modification (NeMo) Tool. The NeMo Tool, using only clinical MRIs, allows estimation of connectome disruption at three levels: whole brain, individual gray matter regions and between pairs of gray matter regions. Partial Least Squares Regression models were constructed for each level of connectome disruption and for each of the three six-month outcomes: applied cognitive, basic mobility and daily activity. Models based on lesion volume were created for comparison. Cross-validation, bootstrapping and multiple comparisons corrections were implemented to minimize over-fitting and Type I errors. The regional disconnection model best predicted applied cognitive (R(2)  = 0.56) and basic mobility outcomes (R(2)  = 0.70), while the pairwise disconnection model best predicted the daily activity measure (R(2)  = 0.72). These results demonstrate that models based on connectome disruption metrics were more accurate than ones based on lesion volume and that increasing anatomical specificity of disconnection metrics does not always increase model accuracy, likely due to statistical adjustments for concomitant increases in data dimensionality. This work establishes that the NeMo Tool's measures of baseline connectome disruption, acquired using only routinely collected MRI scans, can predict 6-month post-stroke outcomes in various functional domains including cognition, motor function and daily activities. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.

Alternate JournalHum Brain Mapp
PubMed ID27016287
PubMed Central IDPMC4905801
Grant ListK23 NS091395 / NS / NINDS NIH HHS / United States
R01 NS034179 / NS / NINDS NIH HHS / United States
P01 NS031318 / NS / NINDS NIH HHS / United States
R01 NS075425 / NS / NINDS NIH HHS / United States
P41 RR023953 / RR / NCRR NIH HHS / United States
R37 NS034179 / NS / NINDS NIH HHS / United States
K23 NS082367 / NS / NINDS NIH HHS / United States