|Title||Rostral anterior cingulate cortex is a structural correlate of repetitive TMS treatment response in depression.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Boes AD, Uitermarkt BD, Albazron FM, Lan MJ, Liston C, Pascual-Leone A, Dubin MJ, Fox MD|
|Date Published||2018 May - Jun|
|Keywords||Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Female, Gyrus Cinguli, Humans, Hypertrophy, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Prefrontal Cortex, Transcranial Magnetic Stimulation, Treatment Outcome|
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for medication-refractory major depression, yet the mechanisms of action for this intervention are poorly understood. Here we investigate cerebral cortex thickness as a possible biomarker of rTMS treatment response.
METHODS: Longitudinal change in cortical thickness is evaluated relative to clinical outcomes across 48 participants in 2 cohorts undergoing left dorsolateral prefrontal cortex rTMS as a treatment for depression.
RESULTS: Our results reveal changes in thickness in a region of the left rostral anterior cingulate cortex that correlate with clinical response, with this region becoming thicker in patients who respond favorably to rTMS and thinner in patients with a less favorable response. Moreover, the baseline cortical thickness in this region correlates with rTMS treatment response - those patients with thinner cortex before treatment tended to have the most clinical improvement.
CONCLUSIONS: This study is the first analysis of longitudinal cortical thickness change with rTMS as a treatment for depression with similar results across two cohorts. These results support further investigation into the use of structural MRI as a possible biomarker of rTMS treatment response.
|Alternate Journal||Brain Stimul|
|PubMed Central ID||PMC6136654|
|Grant List||R01 MH100186 / MH / NIMH NIH HHS / United States |
R25 NS065743 / NS / NINDS NIH HHS / United States
R21 NS085491 / NS / NINDS NIH HHS / United States
K23 NS083741 / NS / NINDS NIH HHS / United States
K12 HD027748 / HD / NICHD NIH HHS / United States
R01 MH113929 / MH / NIMH NIH HHS / United States
R01 NS073601 / NS / NINDS NIH HHS / United States
K12 NS098482 / NS / NINDS NIH HHS / United States
R21 MH099196 / MH / NIMH NIH HHS / United States
R01 HD069776 / HD / NICHD NIH HHS / United States
UL1 RR025758 / RR / NCRR NIH HHS / United States