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The role of microglia and myeloid immune cells in acute cerebral ischemia.

TitleThe role of microglia and myeloid immune cells in acute cerebral ischemia.
Publication TypeJournal Article
Year of Publication2014
AuthorsBenakis C, Garcia-Bonilla L, Iadecola C, Anrather J
JournalFront Cell Neurosci
Volume8
Pagination461
Date Published2014
ISSN1662-5102
Abstract

The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in initiating, sustaining and resolving post-ischemic inflammation. In this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophils in models of cerebral ischemia and to discuss their relevance for human stroke.

DOI10.3389/fncel.2014.00461
Alternate JournalFront Cell Neurosci
PubMed ID25642168
PubMed Central IDPMC4294142
Grant ListR01 NS034179 / NS / NINDS NIH HHS / United States
R01 NS081179 / NS / NINDS NIH HHS / United States
R37 NS034179 / NS / NINDS NIH HHS / United States