| Title | The role of microglia and myeloid immune cells in acute cerebral ischemia. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Benakis C, Garcia-Bonilla L, Iadecola C, Anrather J |
| Journal | Front Cell Neurosci |
| Volume | 8 |
| Pagination | 461 |
| Date Published | 2014 |
| ISSN | 1662-5102 |
| Abstract | The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in initiating, sustaining and resolving post-ischemic inflammation. In this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophils in models of cerebral ischemia and to discuss their relevance for human stroke. |
| DOI | 10.3389/fncel.2014.00461 |
| Alternate Journal | Front Cell Neurosci |
| PubMed ID | 25642168 |
| PubMed Central ID | PMC4294142 |
| Grant List | R01 NS034179 / NS / NINDS NIH HHS / United States R01 NS081179 / NS / NINDS NIH HHS / United States R37 NS034179 / NS / NINDS NIH HHS / United States |