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Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.

TitleProceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.
Publication TypeJournal Article
Year of Publication2021
AuthorsClaassen J, Akbari Y, Alexander S, Bader MKay, Bell K, Bleck TP, Boly M, Brown J, Chou SH-Y, Diringer MN, Edlow BL, Foreman B, Giacino JT, Gosseries O, Green T, Greer DM, Hanley DF, Hartings JA, Helbok R, J Hemphill C, Hinson HE, Hirsch K, Human T, James ML, Ko N, Kondziella D, Livesay S, Madden LK, Mainali S, Mayer SA, McCredie V, McNett MM, Meyfroidt G, Monti MM, Muehlschlegel S, Murthy S, Nyquist P, Olson DWM, J Provencio J, Rosenthal E, Silva GSampaio, Sarasso S, Schiff ND, Sharshar T, Shutter L, Stevens RD, Vespa P, Videtta W, Wagner A, Ziai W, Whyte J, Zink E, Suarez JI
Corporate AuthorsCuring Coma Campaign
JournalNeurocrit Care
Volume35
IssueSuppl 1
Pagination4-23
Date Published2021 Jul
ISSN1556-0961
Abstract

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.

DOI10.1007/s12028-021-01260-x
Alternate JournalNeurocrit Care
PubMed ID34236619
PubMed Central IDPMC8264966
Grant ListR21 NS113037 / NS / NINDS NIH HHS / United States