|Title||Pregnancy and the Risk of Aortic Dissection or Rupture: A Cohort-Crossover Analysis.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Kamel H, Roman MJ, Pitcher A, Devereux RB|
|Date Published||2016 Aug 16|
|Keywords||Adult, Aneurysm, Dissecting, Aortic Rupture, Cohort Studies, Cross-Over Studies, Female, Humans, Pregnancy, Pregnancy Complications, Cardiovascular, Risk Factors, Young Adult|
BACKGROUND: Case series have described aortic dissection and rupture in pregnancy. Few population-based data exist to support an association.
METHODS: We performed a cohort-crossover study using data on all emergency department visits and acute care hospitalizations at nonfederal healthcare facilities in California, Florida, and New York. We included women ≥12 years of age with labor and delivery or abortive pregnancy outcome between 2005 and 2013. Our outcome was a composite of aortic dissection or rupture. Based on the timing of reported aortic complications during pregnancy, we defined the period of risk as 6 months before delivery until 3 months after delivery. We compared each patient's likelihood of aortic complications during this period with an equivalent 270-day period exactly 1 year later. Incidence rates and incidence rate ratios were computed using conditional Poisson regression with robust standard errors.
RESULTS: Among 6 566 826 pregnancies in 4 933 697 women, we identified 36 cases of aortic dissection or rupture during the pregnancy or postpartum period and 9 cases during the control period 1 year later. The rate of aortic complications was 5.5 (95% confidence interval, 4.0-7.8) per million patients during pregnancy and the postpartum period, in comparison with 1.4 (95% confidence interval, 0.7-2.9) per million during the equivalent period 1 year later. Pregnancy was associated with a significantly increased risk of aortic dissection or rupture (incidence rate ratio, 4.0; 95% confidence interval, 2.0-8.2) in comparison with the control period 1 year later.
CONCLUSIONS: The risk of aortic dissection or rupture is elevated during pregnancy and the postpartum period.
|PubMed Central ID||PMC4987245|
|Grant List||FS/08/077/26366 / / British Heart Foundation / United Kingdom |
K23 NS082367 / NS / NINDS NIH HHS / United States
R01 NS097443 / NS / NINDS NIH HHS / United States