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A Novel Neurovascular Liaison Governing the Blood-Brain Barrier.

TitleA Novel Neurovascular Liaison Governing the Blood-Brain Barrier.
Publication TypeJournal Article
Year of Publication2020
AuthorsIshii M, Iadecola C
JournalNeuron
Volume107
Issue2
Pagination205-207
Date Published2020 Jul 22
ISSN1097-4199
Abstract

How circulating signals enter the median eminence to trigger homeostatic hypothalamic responses is not well understood. Jiang et al. describe a neural mechanism that increases endothelial fenestrations and enhances the hypothalamic response to the circulating hormone leptin, suggesting a novel way to regulate brain entry through vascular wall remodeling.

DOI10.1016/j.neuron.2020.06.024
Alternate JournalNeuron
PubMed ID32702343