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Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention.

TitleModulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention.
Publication TypeJournal Article
Year of Publication2017
AuthorsGalkin A, Moncada S
JournalInterface Focus
Volume7
Issue2
Pagination20160104
Date Published2017 Apr 06
ISSN2042-8898
Abstract

In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.

DOI10.1098/rsfs.2016.0104
Alternate JournalInterface Focus
PubMed ID28382200
PubMed Central IDPMC5311904
Grant ListG1100051 / / Medical Research Council / United Kingdom