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The Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.

TitleThe Mitochondrial Unfolded Protein Response as a Non-Oncogene Addiction to Support Adaptation to Stress during Transformation in Cancer and Beyond.
Publication TypeJournal Article
Year of Publication2017
AuthorsKenny TC, Manfredi G, Germain D
JournalFront Oncol
Volume7
Pagination159
Date Published2017
ISSN2234-943X
Abstract

Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPRmt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPRmt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPRmt in other diseases is also emerging and is therefore also briefly discussed.

DOI10.3389/fonc.2017.00159
Alternate JournalFront Oncol
PubMed ID28798902
PubMed Central IDPMC5526845
Grant ListR01 CA172046 / CA / NCI NIH HHS / United States
R01 NS084486 / NS / NINDS NIH HHS / United States