Pfizer COVID-19 vaccine appointments are available to our patients. Sign up for Connect today to schedule your vaccination. Continue your routine care with us by scheduling an in-person appointment or Video Visit.

Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise.

TitleMildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise.
Publication TypeJournal Article
Year of Publication2021
AuthorsGureev AP, Sadovnikova IS, Shaforostova EA, Starkov AA, Popov VN
JournalArch Biochem Biophys
Volume705
Pagination108892
Date Published2021 Apr 27
ISSN1096-0384
Abstract

Exhaustive physical exercises are potentially dangerous for human's physical health and may lead to chronic heart disease. Therefore, individuals involved in such activity require effective and safe cardioprotectors. The goal of this research was to study Mildronate (a cardioprotective drug) effect on the level of oxidative stress markers in hearts of mice under conditions of exhausting physical exercise, such as forced swimming for 1 h per day for 7 days. Forced swimming lead to mtDNA damage accumulation, increase in diene conjugates level and loss of reduced glutathione despite an increase in antioxidant genes expression and activation of mitochondrial biogenesis. Mildronate treatment reduced oxidative stress, probably due to the inhibition of fatty acids transport to mitochondria and an increase in the intensity of glucose oxidation, which in part confirms by increase in glucose transporter expression. Thus, we can assume that Mildronate is an effective cardioprotector in exhaustive physical exercises.

DOI10.1016/j.abb.2021.108892
Alternate JournalArch Biochem Biophys
PubMed ID33930377