Measuring longitudinal myelin water fraction in new multiple sclerosis lesions.

TitleMeasuring longitudinal myelin water fraction in new multiple sclerosis lesions.
Publication TypeJournal Article
Year of Publication2015
AuthorsVargas WS, Monohan E, Pandya S, Raj A, Vartanian T, Nguyen TD, Rúa SMHurtado, Gauthier SA
JournalNeuroimage Clin
Date Published2015
KeywordsAdult, Brain, Female, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Multiple Sclerosis, Myelin Sheath, Water

OBJECTIVES: Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF), an MRI biomarker of myelin, in new MS lesions and to identify factors that influence their subsequent myelin content.

METHODS: Twenty-three MS patients were scanned with whole-brain Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) MWF mapping at baseline and median follow-up of 6 months. Eleven healthy controls (HC) confirmed the reproducibility of FAST-T2 in white matter regions of interests (ROIs) similar to a lesion size. A random-effect-model was implemented to determine the association between baseline clinical and lesion variables and the subsequent MWF.

RESULTS: ROI-based measurements in HCs were highly correlated between scans [mean r = 0.893 (.764-.967)]. In MS patients, 38 gadolinium enhancing (Gd+) and 25 new non-enhancing (Gd-) T2 hyperintense lesions (5.7 months, ±3.8) were identified. Significant improvement in MWF was seen in Gd+ lesions (0.035 ± 0.029, p < 0.001) as compared to Gd- lesions (0.006 ± 0.017, p = 0.065). In the model, a higher baseline MWF (p < 0.001) and the presence of Gd (p < 0.001) were associated with higher subsequent MWF.

CONCLUSIONS: FAST T2 provides a clinically feasible method to quantify MWF in new MS lesions. The observed influence of baseline MWF, which represents a combined effect of both resolving edema and myelin change within acute lesions, suggests that the extent of initial inflammation impacts final myelin recovery.

Alternate JournalNeuroimage Clin
PubMed ID26594620
PubMed Central IDPMC4589846
Grant ListUL1 TR000457 / TR / NCATS NIH HHS / United States
UL1 TR000457-06 / TR / NCATS NIH HHS / United States