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Immune responses to stroke: mechanisms, modulation, and therapeutic potential.

TitleImmune responses to stroke: mechanisms, modulation, and therapeutic potential.
Publication TypeJournal Article
Year of Publication2020
AuthorsIadecola C, Buckwalter MS, Anrather J
JournalJ Clin Invest
Volume130
Issue6
Pagination2777-2788
Date Published2020 Jun 01
ISSN1558-8238
Abstract

Stroke is the second leading cause of death worldwide and a leading cause of disability. Most strokes are caused by occlusion of a major cerebral artery, and substantial advances have been made in elucidating how ischemia damages the brain. In particular, increasing evidence points to a double-edged role of the immune system in stroke pathophysiology. In the acute phase, innate immune cells invade brain and meninges and contribute to ischemic damage, but may also be protective. At the same time, danger signals released into the circulation by damaged brain cells lead to activation of systemic immunity, followed by profound immunodepression that promotes life-threatening infections. In the chronic phase, antigen presentation initiates an adaptive immune response targeted to the brain, which may underlie neuropsychiatric sequelae, a considerable cause of poststroke morbidity. Here, we briefly review these pathogenic processes and assess the potential therapeutic value of targeting immunity in human stroke.

DOI10.1172/JCI135530
Alternate JournalJ. Clin. Invest.
PubMed ID32391806
PubMed Central IDPMC7260029
Grant ListR01 NS081179 / NS / NINDS NIH HHS / United States
R01 NS094507 / NS / NINDS NIH HHS / United States