The Gut-Brain Axis in Parkinson's Disease.

TitleThe Gut-Brain Axis in Parkinson's Disease.
Publication TypeJournal Article
Year of Publication2024
AuthorsGao V, Crawford CV, Burré J
JournalCold Spring Harb Perspect Med
Date Published2024 May 21

Parkinson's disease (PD) involves both the central nervous system (CNS) and enteric nervous system (ENS), and their interaction is important for understanding both the clinical manifestations of the disease and the underlying disease pathophysiology. Although the neuroanatomical distribution of pathology strongly suggests that the ENS is involved in disease pathophysiology, there are significant gaps in knowledge about the underlying mechanisms. In this article, we review the clinical presentation and management of gastrointestinal dysfunction in PD. In addition, we discuss the current understanding of disease pathophysiology in the gut, including controversies about early involvement of the gut in disease pathogenesis. We also review current knowledge about gut α-synuclein and the microbiome, discuss experimental models of PD-linked gastrointestinal pathophysiology, and highlight areas for further research. Finally, we discuss opportunities to use the gut-brain axis for the development of biomarkers and disease-modifying treatments.

Alternate JournalCold Spring Harb Perspect Med
PubMed ID38772708