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New Grants

Academic Year 2022

Hagen Tilgner (PI) 
National Institute on Drug Abuse 1U01DA053625-01
Integrative Single Cell isoform and chromatin accessibility Mapping of Chronic Opioid Exposure in Cognitive Brain Areas in HIV

Academic Year 2021

Hagen Tilgner (PI)
National Institute of General Medical Sciences 3R01GM135247-02S1
Cross-species conservation of cell-type and single-cell specific isoform expression

Kiel Telesford (PI)
National Institute of Neurological Disorders & Stroke 1 K22 NS123508-01
Ethnicity-associated, differential CNS demyelinating autoimmune disease severity: reconciling identity, ancestry and neurotoxic antibody response

Monica Santisteban (PI)
National Institute of Neurological Disorders & Stroke 1 K22 NS123507-01
Neuroimmune Mechanisms of Cognitive Impairment in Salt-sensitive Hypertension

Hibiki Kamawata (PI)
Project ALS 2021-01
Pathogenic mechanisms and therapeutic strategies for CHCHD10 ALS

Giovanni Manfredi (PI)
National Institute of Neurological Disorders and Stroke
Mitochondrial Integrated Stress Response in Neurological Diseases

Nicole Sayles (PI) 
National Heart, Lung, and Blood Institute 
Iron homeostasis alterations in mutant CHCHD10 mitochondria

Chloe Lopez-Lee (PI)
National Institute on Aging 1F31AG072854-01
Elucidating the microglial mechanisms underlying sex-specific neuroinflammation in Alzheimer's Disease

Academic Year 2020

Drs. Anna and Adam Orr (PIs)
Daedalus Fund for Innovation of Weill Cornell Medicine
Site-Specific Blockers of Mitochondrial FreeRadicals for Therapeutic Intervention in Neurodegenerative Diseases

Marilena D'Aurelio (PI)
National Institute of Neurological Disorders and Stroke
Modulation of intermediate metabolism, a new therapeutic approach for mitochondrial encephalomyopathies

Margaret Ross  (PI) 

University of Michigan 1 U54 NS117170-01 PROJECT 1
Epilepsy Multiplatform Variant Prediction (EpiMVP)

Jacqueline Burre (PI)
National Institute of Neurological Disorders & Stroke 1R01NS121077-01
The role of VAMP2 in alpha-synuclein function and pathology

Makoto Ishii (PI)
National Institute on Aging 1R01AG070868-01
Hypothalamic and metabolic dysfunction in Alzheimer's disease

Giuseppe Faraco (PI)
Cure Alzheimer's Fund CAF211776-01
Gut microbiota, endothelial dysfunction and tau-mediated cognitive impairment

Subhash Sinha (PI)
Cure Alzheimer's Fund CAF 212347-01
vHTS for CD33 inhibitors

Giovanni Manfredi (PI) 
National Institute of Neurological Disorders & Stroke 1R01NS120477-01 
Raloxifene-based therapy in neuro degenerative diseases

Natalia De Marco Garcia (PI)
National Institute of Mental Health 1R01MH125006-01 
GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum Disorders

Li Gan (PI) 
Rainwater Charitable Foundation RCF190078-01 
Project 1: Targeting microglial-mediated toxicity treat tauopathy

Giovanni Manfredi (PI)  
National Institute of Neurological Disorders & Stroke 3R01NS112672-02S1 
The role of the mitochondrial protein dimer CHCHD2/10 in health and disease

Margaret Ross  (PI) 
Tri-Institutional Stem Cell Initiative (Weill Cornell) 2019-022 

Li Gan (PI) 
The JPB Foundation JPB194610-02
Targeting maladaptive innate immune response to treat PD

Alicia Che (PI) 
National Institute of Neurological Disorders & Stroke 1 K99 NS114166-01
Maturation of somatosensory circuits for social behaviors

Ping Zhou (PI)
National Institute of Neurological Disorders & Stroke  2R56NS067078-11A1
Role of Prohibitin in Ischemic Brain Injury

Giovanni Manfredi (PI) 
The Friedreich’s Ataxia Research Alliance (FARA)
Mitochondrial integrated stress response in FA cardiomyopathy

Nicholas Schiff (PI)
James S. McDonnell Foundation JSMF 2020-1412
COVID-19 Consortium for Recovery of Consciousness

Virginia Pickel (PI)

Natalia De Marco Garcia (PI) 
National Institute of Neurological Disorders & Stroke 1 R01 NS116137-01A1 
A Circuit Mechanism for the Development of Cortico-cortical Connectivity

Anna Orr (PI) 
National Institute of Aging 1R01AG068091-01
Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation

Wenjie Luo (PI)
National Institute on Aging 1R01AG064239-01A1 
Essential roles of DAP12 in tau metabolism and inflammation in Alzheimer's disease

Anna Orr (PI) 
National Institute of Neurological Disorders & Stroke 1RF1NS118569-01
Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function

Natalia De Marco Garcia (PI)
Irrina T. Hirshl Trust
Irrina T. Hirschl Career Scientist Award

Giovanni Manfredi (PI)
Christina Foundation

Natalia De Marco Garcia (PI)
Brain Research Foundation BRFSG-2020-03
A Circuit Mechanism for the Development of Cortico-cortical Connectivity

Jacqueline Burre (PI)
National Institute of Neurological Disorders & Stroke 1R01NS113960-01A1
The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology

Margaret Ross (PI)
Tri-Institutional Stem Cell Initiative (Weill Cornell) 2019-022

Makoto Ishii (PI)
The Alzheimer's Association AARG-20-681013
Calcium dysregulation and hypothalamic dysfunction in Alzheimer's disease

Kevin McAvoy (PI)
National Institute of Neurological Disorders & Stroke 1F32NS116151-01
Defining the functional role of astrocyte-derived lactate

Jonathan Baker (PI)
National Institute of Neurological Disorders & Stroke 1R01NS111019-01A1
Central thalamic deep brain stimulation to regulate arousal and cognition

Marilena D'Aurelio (PI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1R01AR076029-01A1
Metabolic remodeling of skeletal muscle in mitochondrial myopathies

Esteban Fridman (PI)
National Institute of Neurological Disorders & Stroke 1R21NS109697-01A1
Evaluation of pharmacologically-induced changes in excitatory glutamatergic neurotransmission of severe TBI patients

Hagen Tilgner (PI)
National Institute of General Medical Sciences 1R01GM135247-01
Cross-species conservation of cell-type and single-cell specific isoform expression

Timothy Vartanian (PI)
National Multiple Sclerosis Society RG-1908-34822
Defining ancestry associated B-cell inflammation in treatment naïve

Makoto Ishii (PI)
BrightFocus Foundation A2020363S
Circulating immunometabolic factors in Alzheimer's disease

Jennifer Linden (PI)
Myelin Repair Foundation 
Evaluation of Microglia Derived Extracellular Vesicles in MS Patients with Chronic Active Lesions

Tim Vartanian (PI)
National Institute of Allergy and Infectious Diseases 1R21AI144819-01A1
Determining Enhanced Inflammatory B cell Function in African Americans with MS

Josef Anrather (PI)
Leducq Foundation 19CVD01
Stroke IMPaCT (Stroke Immune Mediated Pathways and Cognitive Trajectory)

Sung Ji Ahn (PI)
American Heart Association 20POST35120063
Pathological tau and neurovascular dysfunction

Academic Year 2019

Jordi Magrane (PI)
Muscular Dystrophy Associations of America, Inc. MDAA 629299
Cell & non-cell autonomous effects of frataxin deficiency in FA pathophysiology

Subhash Sinha (PI)
The JPB Foundation JPG 205199-01
Developing compounds for Alzheimer disease target discovery and therapy

Song-Hai Shi (PI)
Simons Foundation Autism Research Initiative 567854
Defective Lineage-dependent Precise Neocortical Circuit Assembly in ASD 

Anna Orr (PI)
BrightFocus Foundation BFF A2019363S
Selective Blockade of Mitochondrial Free Radicals in AD

Anna Orr (Key Personnel)
National Science Foundation NSF 191335-01 
Elucidating astrocytic mGluR3 signaling using novel light-gated receptors

Yuki Kageyama (PI)  
NARSAD 28470 
Investigate for the Effect of Mitochondrial Oxidative Stress on Prefrontal Circuit and Anhedonic Behavioral Change in Depression

Li Gan (PI) 
The JPB Foundation 
Targeting maladaptive innate immune response to treat PD 

Alicia Che (PI)
Brain & Behavior Research Foundation, 28318 
The Role of Oxytocin in the Emergence of Social Touch

Hagen Tilgner (PI) 
National Institute of Mental Health 1 RF1 MH121267-01 
Single cell isoform expression across mouse brain regions and development

Hooman Kamel (PI) 
National Institute of Neurological Disorders & Stroke   1R01NS106014-01A1
RECONFIG- Recovery of CONsciousness Following Intracerebral hemorrhaGe

Jonathan Victor (PI)
National Eye Institute/NIH/DHHS   5 R01 EY007977-28
Central Processing of Visual Information

Jordi Magrane (PI)
Friedreich's Ataxia Research Alliance/CU FARA CU17-1234
Modeling Friedreich Ataxia in human PSC-derived sensory neuron subtypes

Conor Liston (PI)
National Institute on Drug Abuse 1R01DA047851-01A1
Diagnostic and prognostic biomarkers for subtypes of addiction-related circuit dysfunction

Giovanni Manfredi (PI)
National Institute of Neurological Disorders & Stroke 1R01NS112672-01 
The role of the mitochondrial protein dimer CHCHD2/10 in health and disease

Jonathan Victor (PI)
National Cancer Institute 1R21CA241705-01 
Perceptual sensitivity to anatomical background statistics in mammography

Charles Lynch (PI) 
National Institute of Mental Health 1F32MH120989-01 
Targeting salience network dysfunction in depression with individualized brain network mapping and TMS

Dilek Colak (PI)
National Institute of Mental Health 1R01MH120156-01 
Astrocyte dysfunction in idiopathic autism

Puja Parekh (PI)
National Institute of Mental Health 1F32MH117973-01A1 
Prefrontal circuit mechanisms underlying antidepressant effects of sleep deprivation: a role for metabotropic glutamate receptors

Giovanni Manfredi (PI)
ALS Association, ALS 190452-01
Exploring the disease-modifying effects of EH301 in mouse models of ALS

Conor Liston (PI)
NIMH 1R01MH118388-01
Efficacy of biomarker-guided rTMS for treatment resistant depression

Konrad Csaba (PI)
Muscular Dystrophy Association of America, MDA602762 
Morphometric analysis of fibroblasts for biomarker discovery in sporadic ALS

Giovanni Manfredi (PI)
Muscular Dystrophy Association of America, MDA602894
A novel knock in mouse model to study CHCHD10 mitochondrial diseases

Academic Year 2018

Li Gan (PI)
Rainwater Charitable Foundation, RCF 190078-01
Tau Consortium

Conor Liston (PI)
NIMH 1R01MH118451-01
Regulation of prefrontal cortical circuit function and reward-seeking behavior by
stress-induced dendritic spine remodeling 

Giuseppe Faraco (PI)
Cure Alzheimer's Fund
Dietary salt, tau phosphorylation and cognitive impairment

Jacqueline Burre (PI)
The Michael J. Fox Foundation for Parkinson's Research
Stabilization of synaptic vesicle-bound alpha-synuclein to reduce alpha-synuclein aggregation and pathology in Parkinson’s disease

Giovanni Manfredi (PI)
NINDS (Mt.Sinai Sub) 1R21NS109913-01
Targeting the mitochondrial UPR in familial ALS

Li Gan (PI)
NINDS 7U54NS100717-03
Linking tau proteostasis with neuronal activity in FTD

Karin Hochrainer (PI)
NINDS 1R01NS109588-01
Role of CaMKII-alpha ubiquitination in ischemic stroke

Josef Anrather (PI)
NINDS 2R01NS081179-06
Protective monocytes in cerebral ischemic tolerance

Hibiki Fujita (PI)
NINDS 1R21NS104520-01A1
Targeting astrocytic toxicity for ALS therapy

Timothy Vartanian (PI)
NINDS 1R21NS106581-01A1
An Infectious Etiology for Multiple Sclerosis

Timothy Spellman (PI)
NIMH 1K99MH117271-01
Prefontal Microcircuits Underlying Cognitive Flexibility

Conor Liston (PI)
NIMH 1R56MH114976-01A1
Diagnostic Neuroimaging Biomarkers of Dysfunctional Valence Systems in Depression and Anxiety

Rachel A Babij (PI)
The Instruction of Sensory Inputs in Inhibitory Circuit Maturation in the Somatosensory Cortex

Margaret Ross (PI)
NINDS 1R01NS105477-01A1
Progenitor Regulation Underlying Cortical Interneuron Specification

Laibaik Park (PI)
NINDS 1R01NS097805-01A1
tPA and cerebrovascular regulation in a model of ß-amyloid pathology

Santosh Murthy (PI)
NINDS 1K23NS105948-01
Intracerebral Hemorrhage and Increased Risk of Arterial Thromboembolism

Dilek Colak (PI)
NIMH 1R01MH114888-01A1
Local mRNA degradation in GluR1 signaling, synaptic plasticity, and cognitive

Academic Year 2017

Jordi Magrane (PI)
The Friedreich’s Ataxia Research Alliance (FARA)
Functional analysis of primary sensory neurons and (proprio) sensory pathology
in Friedreich’s ataxia

Virginia Pickel (PI)
NIH grant R01DA042943
Aberrant prefrontal cortical plasticity and neurobehavioral consequences of adolescent marijuana

Thu Huynh (PI)
NARSAD; 1F32MH115654-01
Prefrontal microcircuit mechanisms underlying extinction memory formation

Timothy Vartanian (PI)
NINDS 1R01NS104350-01
Damage Associated Molecular Patterns and Regenerative Failure in MS

Timothy Spellman (PI)
Prefrontal Circuits Supporting Attentional Control

Anna Orr (PI)
Alzheimer's Association
Defining astrocytic-neuronal transcriptional alterations in memory loss

Keith Purpura (PI)
National Eye Institute  1R21EY028336-01
Processing of spatial information in V1 through fixational eye movements

Anna Goldschmidt Orr (PI)
National Institute on Aging  4R00AG048222-03
Roles of Astrocytic G Protein-Coupled Signaling in Memory

Teresa Milner (PI)
NIDA  1T32DA039080-01A1
Genetic and Environmental Influences on Addiction

Michael Glass (PI)
NIH  1R01HL135498-01A1 
Hypothalamic cytokines, glutamate receptor plasticity, and blood pressure

Nicholas Schiff (PI)
Daedalus Fund
Dynamic Multi-lead Deep Brain Stimulation of the Central Thalamus to Treat Chronic Cognitive Deficits in Severe-to-Moderate Traumatic Brain injured Patients

Conor Liston (PI)
Rita Allen Foundation
Prefrontal Circuit Mechanisms for Encoding Working Memory in Hyperexcitable Brain States

Jennifer Linden (PI)
National Multiple Sclerosis Society
Using Endothelial Microparticles to Study Real-Time Blood Brain Barrier Permeability in Multiple Sclerosis Patients

Gregory Petsko (PI)
Target ALS Foundation
Gene Therapeutic modulation of NMD for treatment of ALS

Hooman Kamel (PI)
NIH (Columbia)  1U01NS095869-01A1
AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenicstroke (ARCADIA)

Michael J. Glass (Co-PI)
Teresa A. Milner (Co-PI)
NHLBI  1R01HL136520-01
Contribution of estrogen receptor beta to changes in hypothalamic plasticity and hypertension susceptibility in mice with accelerated ovarian failure

Natalia De Marco Garcia (PI)
Frueauff Foundation Award
A in vivo approach to detect interneuron dysfunction in neurodevelopmental disorders

Jacqueline Burre (PI)
NINDS   1R01NS102181-01  
Molecular mechanisms of Munc18-1 linked infantile seizure disorders and rational rescue strategies

Manu Sharma (PI)
NINDS  1R01NS095988-01A1
Cellular mechanism of Adult Onset Neuronal Ceroid Lipofuscinosis (ANCL) caused by mutations in cysteine string protein-alpha (CSPalpha).

Anatoly Starkov (PI)
NIH (Columbia Sub)
Mitochondrial complex-I as a target for metabolic resuscitation in perinatal hypoxicischemic brain injury

Academic Year 2016

Margaret Elizabeth Ross (PI)
NIH/NICHD 2P01HD067244-06
Risk Genes and Environmental Interactions in Neural Tube Defects

Costantino Iadecola  (PI)
NIH/NINDS 1R01NS100447-01
ApoE4 and mechanisms of diffuse white matter injury 

Daniel J Thengone (PI)
NIH/NEI F31EY025535
Neuronal interactions during sensory adaptation 

Manu Sharma (PI)
NIH/NIA 1R01AG052505-01
DnaJ co-chaperones which modify tau aggregation and neurodegeneration

Natalia DeMarco (PI)
NIH/NIMH 1R01MH110553-01
Neural mechanism for the assembly of GABAergic circuits in the cerebral cortex

Hooman Kamel (PI)
NIH/NINDS 1 R01 NS097443-01
Left Atrial abNormality, ThromboEmbolism, and Race: Novel risk factors for stroke (LANTERN)

Costantino Iadecola (Co-PI)
Giovanni Manfredi (Co-PI)
NIH/NINDS 1R01NS095692-01A1
Estrogen receptor beta and mitochondrial permeability transition in Ca2+ induced neuronal injury

Conor Liston (PI)
NIH/NIMH 1R01MH109685
Prefrontal cortical microcircuit mechanisms of working memory deficits in chronic stress

Wenjie Luo (PI)
BrightFocus Foundation
Retromer chaperone R33 selectively promotes Abeta degradation by microglia

Giovanni Manfredi (PI)
Muscular Dystrophy Association
CHCHD10 in familial ALS

Jonathan Victor (PI)
National Science Foundation
Collaborative Research: Olfactory Navigation: Dynamic Computing in the Natural Environment

Costantino Iadecola (PI)
NIH/NINDS 1R01 NS095441
Dietary sodium, neurovascular dysfunction and cerebrovascular risk

M. Flint Beal (PI)
CURE Parkinson’s Disease
Preventing lipid peroxidation to rescue alpha-synuclein toxicity in vivo

Wenjie Luo (PI)
Sanofi Innovation Award
Search for small molecules promoting tau clearance by microglia

Natalia DeMarco (PI)
Citizens United for Research in Epilepsy
Regulation of cortical interneuron migration and epilepsy

Nicholas Schiff (PI)
NINDS BRAIN Initiative
Central thalamic stimulation for traumatic brain injury

Conor Liston (PI) 
IMHRO Rising Star Award
Circuit biomarkers for diagnosing and treating neurophysiological subtypes of depression

Academic Year 2015

Manu Sharma (PI)
Alzheimer's Association
Tau Proteostasis by Cysteine String Protein-alpha (CSP-alpha)

Jonathan Victor (PI)
NIH R01EY007977 (competitive renewal)
Central Processing of Visual Information

Jacqueline Burre (PI)
American Parkinson's Disease Association
Aging increases the aggregation-prone cytosolic pool of alpha-synuclein

Manu Sharma (PI)
AFAR New Investigator Award in Alzheimer’s Disease Research
Tau Proteostasis by Hsc70 Co-Chaperones

Costantino Iadecola (PI) 
NIH 1R37NS089323 (Javits Award) 
Hypertension and neurovascular dysfunction  

Ping Zhou (PI)
NIH 5R01NS067078 (competitive renewal)
Role of Prohibitin in Ischemic Brain Injury 

Esteban Fridman (PI)
NIH 1R21NS093268
Specification of dopaminergic synaptic disorders severe brain injury 

Giovanni Manfredi (PI)
NIH 1R01NS093872
Metabolic profiling of sporadic ALS patients 

Teresa A. Milner (PI)
NIH 2R01 DA 008529-21 (competitive renewal)
Stress-opioid interaction in hippocampus

Conor Liston (PI)
Hartwell Foundation 
Neuroimaging biomarkers in autism spectrum disorders 

Makoto Ishii (PI
Bright Focus Foundation 
Pathological role of amyloid-beta on adipocyte hormone signaling

Jacqueline Burre (PI) 
The American Epilepsy Society and the Epilepsy Foundation
Dysfunction of STXBP1 in infantile epileptic encephalopathies

Jacqueline Burre (PI)
Leon Levy Foundation Grant
Function and Dysfunction of Synucleins at the Synapse

Wenjie Luo (PI)
Cart Foundation
Investigating the role of microglia in tau clearance in Alzheimer’s disease

Jordi Magrane (PI)
The Friedreich’s Ataxia Research Alliance (FARA)
Approaches to correct mitochondrial abnormalities and synaptic pathology in frataxin-deficient sensory neurons


Weill Cornell Medicine Feil Family Brain & Mind Research Institute 407 E 61st St New York, NY 10065 Phone: (646) 962-8277 Fax: (646) 962-0535