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Effects of COVID-19 on the Nervous System.

TitleEffects of COVID-19 on the Nervous System.
Publication TypeJournal Article
Year of Publication2020
AuthorsIadecola C, Anrather J, Kamel H
JournalCell
Volume183
Issue1
Pagination16-27.e1
Date Published2020 10 01
ISSN1097-4172
KeywordsAnimals, Brain Diseases, Cardiopulmonary Resuscitation, Coronavirus Infections, Humans, Olfaction Disorders, Pandemics, Pneumonia, Viral, Stroke
Abstract

Neurological complications have emerged as a significant cause of morbidity and mortality in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized patients exhibit neurological manifestations ranging from headache and loss of smell, to confusion and disabling strokes. COVID-19 is also anticipated to take a toll on the nervous system in the long term. Here, we will provide a critical appraisal of the potential for neurotropism and mechanisms of neuropathogenesis of SARS-CoV-2 as they relate to the acute and chronic neurological consequences of the infection. Finally, we will examine potential avenues for future research and therapeutic development.

DOI10.1016/j.cell.2020.08.028
Alternate JournalCell
PubMed ID32882182
PubMed Central IDPMC7437501
Grant ListR01 NS034179 / NS / NINDS NIH HHS / United States
R01 NS094507 / NS / NINDS NIH HHS / United States
R01 NS095441 / NS / NINDS NIH HHS / United States
R01 NS097443 / NS / NINDS NIH HHS / United States
U01 NS095869 / NS / NINDS NIH HHS / United States
R37 NS089323 / NS / NINDS NIH HHS / United States
R01 NS100447 / NS / NINDS NIH HHS / United States
R01 NS081179 / NS / NINDS NIH HHS / United States