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Feil Family Brain & Mind Research Institute

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Dangerous leaks: blood-brain barrier woes in the aging hippocampus.

TitleDangerous leaks: blood-brain barrier woes in the aging hippocampus.
Publication TypeJournal Article
Year of Publication2015
AuthorsIadecola C
Date Published2015 Jan 21
KeywordsAging, Blood-Brain Barrier, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Cognitive Dysfunction, Dentate Gyrus, Female, Humans, Male

A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration, but reliable human data were lacking. Here, Montagne et al. (2015) provide the first in vivo evidence of blood-brain barrier disruption in the aging hippocampus and in minimal cognitive impairment.

Alternate JournalNeuron
PubMed ID25611503
PubMed Central IDPMC4731877
Grant ListR01 NS037853 / NS / NINDS NIH HHS / United States