| Title | Dangerous leaks: blood-brain barrier woes in the aging hippocampus. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Iadecola C |
| Journal | Neuron |
| Volume | 85 |
| Issue | 2 |
| Pagination | 231-3 |
| Date Published | 2015 Jan 21 |
| ISSN | 1097-4199 |
| Keywords | Aging, Blood-Brain Barrier, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Cognitive Dysfunction, Dentate Gyrus, Female, Humans, Male |
| Abstract | A leaky blood-brain barrier has long been implicated in cognitive dysfunction in aging and neurodegeneration, but reliable human data were lacking. Here, Montagne et al. (2015) provide the first in vivo evidence of blood-brain barrier disruption in the aging hippocampus and in minimal cognitive impairment. |
| DOI | 10.1016/j.neuron.2014.12.056 |
| Alternate Journal | Neuron |
| PubMed ID | 25611503 |
| PubMed Central ID | PMC4731877 |
| Grant List | R01 NS037853 / NS / NINDS NIH HHS / United States |