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Commentary on Myers et al.: growing role of the innate immunity receptor CD36 in central nervous system diseases.

TitleCommentary on Myers et al.: growing role of the innate immunity receptor CD36 in central nervous system diseases.
Publication TypeJournal Article
Year of Publication2014
AuthorsGarcia-Bonilla L, Park L, Iadecola C
JournalExp Neurol
Volume261
Pagination633-7
Date Published2014 Nov
ISSN1090-2430
KeywordsAnimals, CD36 Antigens, Central Nervous System Diseases, Humans, Immunity, Innate, Signal Transduction
Abstract

Activation of innate immunity by sterile inflammation has emerged as a key event in selected CNS diseases, with a defining impact on all stages of the pathological process. Due to its multiple functions and assembly with other pattern recognition receptors, the innate immunity receptor CD36 has been implicated in a wide variety of brain pathologies, ranging from acute brain injury to neurodegeneration. However, the role of CD36 is complex involving both tissue destruction, related mainly to oxidative stress and inflammation, and beneficial reparative effects due to the involvement of CD36 in tissue repair and reorganization. A recent paper of Meyer at al. provided novel evidence for a role of CD36 also in spinal cord trauma, a condition in which the effect of CD36 was found to be univocally deleterious. This commentary will provide a brief overview of the pathobiology of CD36 and its expanding role in diseases of the brain and spinal cord.

DOI10.1016/j.expneurol.2014.08.016
Alternate JournalExp. Neurol.
PubMed ID25157902
PubMed Central IDPMC4724057
Grant ListR01 NS037853 / NS / NINDS NIH HHS / United States
R01 NS034179 / NS / NINDS NIH HHS / United States
NS37853 / NS / NINDS NIH HHS / United States
R37 NS034179 / NS / NINDS NIH HHS / United States
NS34179 / NS / NINDS NIH HHS / United States