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The cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits.

TitleThe cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits.
Publication TypeJournal Article
Year of Publication2019
AuthorsTsai S-YA, Bendriem RM, Lee C-TD
JournalNeurobiol Stress
Volume10
Pagination100145
Date Published2019 Feb
ISSN2352-2895
Abstract

Prenatal substance exposure is a growing public health concern worldwide. Although the opioid crisis remains one of the most prevalent addiction problems in our society, abuse of cocaine, methamphetamines, and other illicit drugs, particularly amongst pregnant women, are nonetheless significant and widespread. Evidence demonstrates prenatal drug exposure can affect fetal brain development and thus can have long-lasting impact on neurobehavioral and cognitive performance later in life. In this review, we highlight research examining the most prevalent drugs of abuse and their effects on brain development with a focus on endoplasmic reticulum stress and oxidative stress signaling pathways. A thorough exploration of drug-induced cellular stress mechanisms during prenatal brain development may provide insight into therapeutic interventions to combat effects of prenatal drug exposure.

DOI10.1016/j.ynstr.2018.100145
Alternate JournalNeurobiol Stress
PubMed ID30937351
PubMed Central IDPMC6430408