Babak Navi Program

Babak B. Navi, M.D., M.S.
Assistant Professor of Neurology
Assistant Professor of Neuroscience, BMRI
Associate Director of the Clinical and Translational Neuroscience Unit

My Mission

I am an academic neurologist with specialty training in stroke and clinical research, particularly epidemiological research. As a member of the Brain and Mind Research Institute, I conduct clinical trials, observational studies, and meta-analyses in order to advance our understanding of the risk factors and mechanisms of vascular disease in the brain. My primary research interest is the relationship between stroke and cancer—two common and morbid diseases with immense pubic health impacts. 

Click here for more information on Dr. Babak's Neurology Practice

Goals

My short-term goals are to determine why patients with cancer suffer stroke and how to best treat these patients to prevent recurrent stroke. I also plan to determine what the effects of cancer type, stage, and treatments are on patients’ stroke risk. 

My long-term goal is to reduce the incidence and burden of stroke in patients with cancer. I plan to do this by elucidating the complex relationship between stroke and cancer, which will enable the identification and targeted treatment of cancer patients at high risk for stroke. 

Achievements 

• I have published over 50 peer-reviewed articles on stroke, including many in top-tier journals, such as Stroke, Neurology, Annals of Neurology, Annals of Emergency Medicine, JAMA, and New England Journal of Medicine
• National Institutes of Health K23 grant recipient, 2015
• Associate Editor for the Neurohospitalist journal, 2015
• Florence Gould Endowment for Discovery in Stroke recipient, 2013
• National Institutes of Health KL2 grant recipient through the Weill Cornell Clinical and Translational Science Center, 2012
• Brain Attack and Cerebrovascular Disease Conference Co-Director, 2012-present

Select Publications

• Navi BB, Reichman JS, Berlin D, Reiner AS, Panageas KS, Segal AZ, DeAngelis LM. Intracerebral and subarachnoid hemorrhage in patients with cancer.  Neurology 2010;74:494-501.
• Kamel H, Navi BB, Nakagawa K, Hemphill JC, Ko N. Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: A meta-analysis of randomized clinical trials.  Crit Care Med 2011;39:554-559.
• Navi BB, Kamel H, Sidney S, Klingman J, Nguyen-Huynh MN, Johnston SC. Validation of the stroke prognostic instrument-II in a large, modern, community-based cohort of ischemic stroke survivors.  Stroke 2011;42:3392-3396.
• Navi BB, Kamel H, McCulloch CE, Nakagawa K, Naravetla B, Moheet AM, Wong C, Johnston SC, Hemphill JC, Smith WS. Accuracy of neurovascular fellows’ prognostication of outcome after subarachnoid hemorrhage. Stroke 2012;43:702-707.
• Kamel H, Navi BB, Fahimi J. National trends in ambulance use by patients with stroke, 1997-2008. JAMA 2012;307:1026-1028.
• Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. Application of the ABCD2 score to identify cerebrovascular causes of dizziness in the emergency department. Stroke 2012;43:1484-1489.
• Reichman J, Singer S, Navi BB, Reiner A, Panageas K, Gutin PH, DeAngelis LM. Subdural hematoma in patients with cancer. Neurosurgery 2012;71:74-79.
• Navi BB, Kamel H, Hemphill JC, Smith WS. Trajectory of functional recovery after hospital discharge for subarachnoid hemorrhage. Neurocrit Care 2012;17:343-347.
• Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. Rate and Predictors of Serious Neurological Causes of Dizziness in the Emergency Department. Mayo Clin Proc 2012;87:1080-1088.
• Navi BB, Kamel H, Shah MP, Grossman AW, Wong C, Poisson SN, Whetstone WD, Josephson SA, Johnston SC, Kim AS. The use of neuroimaging studies and neurological consultation to evaluate dizzy patients in the emergency department. Neurohospitalist 2013;3:7-14.
• Kamel H, Fahimi J, Govindarajan P, Navi BB. Nationwide patters of hospitalization after transient ischemic attack. J Stroke Cerebrovasc Dis 2013;22:e142-145.
• Kamel H, Navi BB, Elijovich L, Josephson SA, Yee AH, Fung G, Johnston SC, Smith WS. Pilot randomized trial of outpatient cardiac monitoring after cryptogenic stroke. Stroke 2013;44:528-530.
• Guterman EL, Kamel H, Azran C, Shah MP, Hemphill JC, Smith WS, Navi BB. Time from onset of SIRS to antibiotic administration and outcomes after subarachnoid hemorrhage. Neurocrit Care 2014;21:85-90.
• Kamel H, Navi BB, Sriram N, Hovsepian DA, Devereux RB, Elkind MSV. Risk of a thrombotic event after the 6-week postpartum period. N Engl J Med 2014;370:1307-1315.
• Navi BB, Singer S, Merkler AE, Cheng NT, Stone JB, Kamel H, Iadecola C, Elkind MSV, DeAngelis LM. Recurrent thromboembolic events after ischemic stroke in patients with cancer. Neurology 2014;83:26-33.
• Hovsepian DA, Sriram N, Kamel H, Fink ME, Navi BB. Acute cerebrovascular disease occurring after hospital discharge for labor and delivery. Stroke 2014;45:1947-1950.
• Navi BB, Singer S, Merkler AE, Cheng NT, Stone JB, Kamel H, Iadecola C, Elkind MSV, DeAngelis LM. Cryptogenic subtype predicts reduced survival among cancer patients with ischemic stroke. Stroke 2014;45:2292-2297.
• Navi BB, Reiner AS, Kamel H, Iadecola C, Elkind MSV, Panageas KS, DeAngelis LM. Association between incident cancer and subsequent stroke. Ann Neurol 2015;77:291-300.
• Kuceyski A, Navi BB, Kamel H, Relkin N, Villanueva M, Raj A, Toglia J, O’Dell M, Iadecola C. Exploring the brain’s structural connectome: a quantitative stroke lesion-dysfunction mapping study. Hum Brain Mapp 2015;36:2147-2160.
• Merkler AE, Navi BB, Singer S, Cheng NT, Stone JB, Kamel H, Iadecola C, Elkind MSV, DeAngelis LM. Diagnostic yield of echocardiography in cancer patients with ischemic stroke. J Neurooncol 2015;123:115-121.
• Kummer BR, Gialdini G, Sevush JL, Kamel H, Patsalides A, Navi BB. External validation of the Cincinnati Prehospital Stroke Severity Scale. J Stroke Cerebrovasc Dis. Epub ahead of print March 9, 2016.
• Navi BB, Parikh NS, Lerario MP, Merkler AE, Lappin RI, Fahimi J, Iadecola C, Kamel H. Risk of intracerebral hemorrhage after emergency department discharges for hypertension. J Stroke Cerebrovasc Dis. In press.
• Murthy SB, Shastri A, Merkler AE, Hanley DF, Zai WC, Fink ME, Iadecola C, Kamel H, Navi BB. Intracerebral hemorrhage outcomes in patients with systemic cancer. J Stroke Cerebrovasc Dis. Epub ahead of print August 25, 2016.

Joint Appointments

I am an Assistant Professor of Neurology at Weill Cornell Medical College and an Assistant Member (Level 1) at the Memorial Sloan-Kettering Cancer Center. 

Collaborations

Frequent collaborators within the college are Costantino Iadecola, Lisa DeAngelis, Ashish Raj, Hooman Kamel, Ajay Gupta, and Amy Kuceyeski.