|Astrocytes as Drivers and Disruptors of Behavior: New Advances in Basic Mechanisms and Therapeutic Targeting.
|Year of Publication
|Barnett D, Bohmbach K, Grelot V, Charlet A, Dallérac G, Ju YHa, Nagai J, Orr AG
|2023 Nov 08
|Astrocytes, Cognition, Cognitive Dysfunction, Humans
Astrocytes are emerging as key regulators of cognitive function and behavior. This review highlights some of the latest advances in the understanding of astrocyte roles in different behavioral domains across lifespan and in disease. We address specific molecular and circuit mechanisms by which astrocytes modulate behavior, discuss their functional diversity and versatility, and highlight emerging astrocyte-targeted treatment strategies that might alleviate behavioral and cognitive dysfunction in pathologic conditions. Converging evidence across different model systems and manipulations is revealing that astrocytes regulate behavioral processes in a precise and context-dependent manner. Improved understanding of these astrocytic functions may generate new therapeutic strategies for various conditions with cognitive and behavioral impairments.
|PubMed Central ID
|F31 AG084165 / AG / NIA NIH HHS / United States
R00 AG048222 / AG / NIA NIH HHS / United States
RF1 NS118569 / NS / NINDS NIH HHS / United States