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Alzheimer Disease
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2
Kumar A
,
Karuppagounder SS
,
Chen Y
,
Corona C
,
Kawaguchi R
,
Cheng Y
,
Balkaya M
,
Sagdullaev BT
,
Wen Z
,
Stuart C
et al.
. 2023.
2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience.
.
Neuron. 111(18):2831-2846.e10.
A
Luo W
,
Qu W
,
Gan L
. 2023.
The AD odyssey 2023: Tales of single cell.
.
Cell. 186(20):4257-4259.
Das M
,
Mao W
,
Voskobiynyk Y
,
Necula D
,
Lew I
,
Petersen C
,
Zahn A
,
Yu G-Q
,
Yu X
,
Smith N
et al.
. 2023.
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
.
Neurobiol Dis. 186:106263.
Del Prete D
,
Rice RC
,
Rajadhyaksha AM
,
D'Adamio L
. 2016.
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
.
J Biol Chem. 291(33):17209-27.
Cheng F
,
Wang F
,
Tang J
,
Zhou Y
,
Fu Z
,
Zhang P
,
Haines JL
,
Leverenz JB
,
Gan L
,
Hu J
et al.
. 2024.
Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.
.
Cell Rep Med. 5(2):101379.
B
Uekawa K
,
Hattori Y
,
Ahn SJi
,
Seo J
,
Casey N
,
Anfray A
,
Zhou P
,
Luo W
,
Anrather J
,
Park L
et al.
. 2023.
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.
.
Mol Neurodegener. 18(1):73.
E
Koizumi K
,
Wang G
,
Park L
. 2016.
Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations.
.
Cell Mol Neurobiol. 36(2):155-65.
F
Yang X
,
Wen J
,
Yang H
,
Jones IR
,
Zhu X
,
Liu W
,
Li B
,
Clelland CD
,
Luo W
,
Wong MYing
et al.
. 2023.
Functional characterization of Alzheimer's disease genetic variants in microglia.
.
Nat Genet. 55(10):1735-1744.
I
Zhao L
,
Gottesdiener AJ
,
Parmar M
,
Li M
,
Kaminsky SM
,
Chiuchiolo MJ
,
Sondhi D
,
Sullivan PM
,
Holtzman DM
,
Crystal RG
et al.
. 2016.
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
.
Neurobiol Aging. 44:159-172.
K
Kauwe G
,
Pareja-Navarro KA
,
Yao L
,
Chen JH
,
Wong I
,
Saloner R
,
Cifuentes H
,
Nana AL
,
Shah S
,
Li Y
et al.
. 2024.
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.
.
J Clin Invest. 134(3)
L
McGuire MJ
,
Ishii M
. 2016.
Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.
.
Cell Mol Neurobiol. 36(2):203-17.
M
Ishii M
,
Iadecola C
. 2015.
Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.
.
Cell Metab. 22(5):761-76.
Luo W
,
Liu W
,
Hu X
,
Hanna M
,
Caravaca A
,
Paul SM
. 2015.
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
.
Sci Rep. 5:11161.
N
Xia D
,
Lianoglou S
,
Sandmann T
,
Calvert M
,
Suh JH
,
Thomsen E
,
Dugas J
,
Pizzo ME
,
DeVos SL
,
Earr TK
et al.
. 2022.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
.
Mol Neurodegener. 17(1):41.
S
Eruysal E
,
Ravdin L
,
Zhang C
,
Kamel H
,
Iadecola C
,
Ishii M
. 2023.
Sexually Dimorphic Association of Circulating Plasminogen Activator Inhibitor-1 Levels and Body Mass Index with Cerebrospinal Fluid Biomarkers of Alzheimer's Pathology in Preclinical Alzheimer's Disease.
.
J Alzheimers Dis. 91(3):1073-1083.
T
Hu X
,
Li X
,
Zhao M
,
Gottesdiener A
,
Luo W
,
Paul S
. 2014.
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.
.
Mol Neurodegener. 9:52.
Ishii M
,
Wang G
,
Racchumi G
,
Dyke JP
,
Iadecola C
. 2014.
Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.
.
J Neurosci. 34(27):9096-106.
Evering TH
,
Marston JL
,
Gan L
,
Nixon DF
. 2023.
Transposable elements and Alzheimer's disease pathogenesis.
.
Trends Neurosci. 46(3):170-172.
Yuan P
,
Condello C
,
C Keene D
,
Wang Y
,
Bird TD
,
Paul SM
,
Luo W
,
Colonna M
,
Baddeley D
,
Grutzendler J
. 2016.
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
.
Neuron. 90(4):724-39.
V
Iadecola C
. 2016.
Vascular and Metabolic Factors in Alzheimer's Disease and Related Dementias: Introduction.
.
Cell Mol Neurobiol. 36(2):151-4.
X
Yan Y
,
Wang X
,
Chaput D
,
Shin M-K
,
Koh Y
,
Gan L
,
Pieper AA
,
Woo J-AA
,
Kang DE
. 2022.
X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.
.
Cell. 185(21):3913-3930.e19.