Feil Family Brain & Mind Research Institute

Publications

Found 57 results

Author Title [ Type

] Year

Filters: Author is Gan, Li [Clear All Filters]

Journal Article

Honey MIJ, Hok-A-Hin YS, Thijssen EH, Cousins KAQ, van der Weijden B, Veld LIn 't, Stoops E, de Boer SCM, Duits FH, de Houwer JFH et al.. 2026. An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration.. Nat Med.

Luo W, Qu W, Gan L. 2023. The AD odyssey 2023: Tales of single cell.. Cell. 186(20):4257-4259.

Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu G-Q, Yu X, Smith N et al.. 2023. Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.. Neurobiol Dis. 186:106263.

Carling GK, Fan L, Foxe NR, Norman K, Wong MYing, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. Neuron.

Carling GK, Fan L, Foxe NR, Norman K, Ye P, Wong MYing, Zhu D, Yu F, Xu J, Yarahmady A et al.. 2024. Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.. bioRxiv.

Bravo CParra, Krukowski K, Barker S, Wang C, Li Y, Fan L, Vázquez-Rosa E, Shin M-K, Wong MYing, McCullough LD et al.. 2024. Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.. Mol Neurodegener. 19(1):51.

Han L, Gan L. 2022. The Application of Artificial Neural Network Combined with Virtual Reality Technology in Environment Art Design.. Comput Intell Neurosci. 2022:7562167.

Cheng F, Wang F, Tang J, Zhou Y, Fu Z, Zhang P, Haines JL, Leverenz JB, Gan L, Hu J et al.. 2024. Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease.. Cell Rep Med. 5(2):101379.

Amin S, Liu B, Gan L. 2023. Autophagy prevents microglial senescence.. Nat Cell Biol. 25(7):923-925.

Lee S-I, Luo W, Gan L. 2026. CAR-A astrocytes for Alzheimer's: Promise and challenge.. Cell Stem Cell. 33(5):720-721.

Khawaja RR, Griego E, Lindenau K, Salek A, Gambardella J, Scrivo A, Monday HR, Bourdenx M, Madero-Pérez J, Khan ZN et al.. 2025. Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.. Nat Cell Biol. 27(10):1688-1707.

Hu W, Foord C, Hsu J, Fan L, Corley MJ, Lanjewar SN, Xu S, Belchikov N, He Y, Pang APS et al.. 2025. Combined single-cell profiling of chromatin-transcriptome and splicing across brain cell types, regions and disease state.. Nat Biotechnol.

Gan L, Cookson MR, Petrucelli L, La Spada AR. 2018. Converging pathways in neurodegeneration, from genetics to mechanisms.. Nat Neurosci. 21(10):1300-1309.

Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CParra, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D et al.. 2023. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.. bioRxiv.

Dräger NM, Sattler SM, Huang CTzu-Ling, Teter OM, Leng K, Hashemi SHadi, Hong J, Aviles G, Clelland CD, Zhan L et al.. 2022. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.. Nat Neurosci.

Chen H, Fan L, Guo Q, Wong MYing, Yu F, Foxe N, Wang W, Nessim A, Carling G, Liu B et al.. 2023. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.. bioRxiv.

Chen H, Fan L, Guo Q, Wong MYing, Yu F, Foxe N, Wang W, Nessim A, Carling G, Liu B et al.. 2023. DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.. Res Sq.

Chen H, Fan L, Guo Q, Wong MYing, Zhu J, Foxe N, Wang W, Nessim A, Carling G, Liu B et al.. 2025. DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice.. Mol Neurodegener. 20(1):124.

Telpoukhovskaia MA, Liu K, Sayed FA, Etchegaray JIker, Xie M, Zhan L, Li Y, Zhou Y, Le D, Bahr BA et al.. 2020. Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.. Sci Rep. 10(1):13688.

Wang Z, Lipshutz A, Liu Z-L, Trzeciak AJ, Miranda IC, de la Torre CMartínez, Schild T, Lazarov T, Rojas WSaitz, Saavedra PHV et al.. 2023. Early life high fructose exposure disrupts microglia function and impedes neurodevelopment.. bioRxiv.

Wang Z, Lipshutz A, de la Torre CMartínez, Trzeciak AJ, Liu Z-L, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A et al.. 2025. Early life high fructose impairs microglial phagocytosis and neurodevelopment.. Nature.

Chen X, Gan L. 2019. An exercise-induced messenger boosts memory in Alzheimer's disease.. Nat Med. 25(1):20-21.

Dong Q, Gentry NW, McMahon T, Yamazaki M, Benitez-Rivera L, Wang T, Gan L, Ptáček L, Fu Y-H. 2022. Familial natural short sleep mutations reduce Alzheimer pathology in mice.. iScience. 25(4):103964.

Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MYing et al.. 2023. Functional characterization of Alzheimer's disease genetic variants in microglia.. Nat Genet. 55(10):1735-1744.

Sziraki A, Lu Z, Lee J, Banyai G, Anderson S, Abdulraouf A, Metzner E, Liao A, Banfelder J, Epstein A et al.. 2023. A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains.. Nat Genet.